Life Course Associations Between Ambient Fine Particulate Matter and the Prevalence of Prediabetes and Diabetes: A Longitudinal Cohort Study in Taiwan and Hong Kong

IF 14.8 1区 医学 Q1 ENDOCRINOLOGY & METABOLISM Diabetes Care Pub Date : 2024-11-12 DOI:10.2337/dc24-1041
Yuanyuan Yi, Cui Guo, Yiling Zheng, Siyi Chen, Changqing Lin, Alexis K. H. Lau, Martin C. S. Wong, David M. Bishai
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Abstract

OBJECTIVE Both air pollution and diabetes are key urban challenges. The association between particulate matter with a diameter of <2.5 μm (PM2.5) exposure and prediabetes/diabetes in adults is well documented, but the health effects of life course exposure remain unclear. This study evaluated the impact of PM2.5 exposure throughout various life stages on the prevalence of prediabetes/diabetes in adulthood. RESEARCH DESIGN AND METHODS We included 4,551 individuals with 19,593 medical visits from two open cohorts in Taiwan and Hong Kong between 2000 and 2018. Ambient PM2.5 exposure was assessed using a satellite-based model, delivering a 2-year average exposure at a resolution of 1 km2. Logistic mixed-effects models were used to investigate longitudinal associations between PM2.5 exposure and the prevalence of prediabetes/diabetes. Life course models were used to examine the impact of PM2.5 exposure at different life stages on prediabetes/diabetes in adulthood. RESULTS Over an average follow-up period of 9.93 years, 1,660 individuals with prediabetes/diabetes were observed. For the longitudinal association, every 10 μg/m3 increase in PM2.5 was associated with an increased odds of having prediabetes/diabetes (odds ratio 1.32, 95% CI 1.13, 1.54). The odds of adulthood prediabetes/diabetes increased by 15%, 18%, and 29% for each 10 μg/m3 increase in PM2.5 exposure during school age, adolescence, and adulthood, respectively. CONCLUSIONS Our findings suggest a link between PM2.5 exposure during each life stage and the prevalence of prediabetes/diabetes in adulthood, with the health impacts of exposure during adulthood being slightly greater. This study underscores the need for life course air pollution control strategies to mitigate the substantial disease burden of diabetes.
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环境细颗粒物与糖尿病前期和糖尿病患病率之间的生命历程关联:台湾和香港的纵向队列研究
目的 空气污染和糖尿病都是城市面临的主要挑战。直径为<2.5 μm(PM2.5)的颗粒物暴露与成人糖尿病前期/糖尿病之间的关系已得到充分证实,但生命过程中的暴露对健康的影响仍不清楚。本研究评估了不同生命阶段的PM2.5暴露对成年后糖尿病前期/糖尿病患病率的影响。研究设计与方法 我们纳入了2000年至2018年期间台湾和香港两个开放队列中的4551人,他们共就诊19593次。环境 PM2.5 暴露使用基于卫星的模型进行评估,以 1 平方公里的分辨率提供 2 年的平均暴露量。采用逻辑混合效应模型研究 PM2.5 暴露与糖尿病前期/糖尿病患病率之间的纵向联系。生命历程模型用于研究不同生命阶段的 PM2.5 暴露对成年后糖尿病前期/糖尿病的影响。结果 在平均 9.93 年的随访期间,共观察到 1,660 名糖尿病前期/糖尿病患者。就纵向关联而言,PM2.5每增加10微克/立方米,糖尿病前期/糖尿病患者的几率就会增加(几率比1.32,95% CI 1.13,1.54)。在学龄期、青春期和成年期,PM2.5暴露量每增加10微克/立方米,成年后患糖尿病前期/糖尿病的几率分别增加15%、18%和29%。结论 我们的研究结果表明,每个生命阶段的 PM2.5 暴露与成年期糖尿病前期/糖尿病患病率之间存在联系,成年期暴露对健康的影响稍大。这项研究强调,有必要采取生命过程空气污染控制策略,以减轻糖尿病带来的巨大疾病负担。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Diabetes Care
Diabetes Care 医学-内分泌学与代谢
CiteScore
27.80
自引率
4.90%
发文量
449
审稿时长
1 months
期刊介绍: The journal's overarching mission can be captured by the simple word "Care," reflecting its commitment to enhancing patient well-being. Diabetes Care aims to support better patient care by addressing the comprehensive needs of healthcare professionals dedicated to managing diabetes. Diabetes Care serves as a valuable resource for healthcare practitioners, aiming to advance knowledge, foster research, and improve diabetes management. The journal publishes original research across various categories, including Clinical Care, Education, Nutrition, Psychosocial Research, Epidemiology, Health Services Research, Emerging Treatments and Technologies, Pathophysiology, Complications, and Cardiovascular and Metabolic Risk. Additionally, Diabetes Care features ADA statements, consensus reports, review articles, letters to the editor, and health/medical news, appealing to a diverse audience of physicians, researchers, psychologists, educators, and other healthcare professionals.
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