Metal-organic framework-hydrogel composites as emerging platforms for enhanced wound healing applications: Material design, therapeutic strategies, and future prospects

IF 3.5 3区医学 Q2 CHEMISTRY, MEDICINAL ACS Medicinal Chemistry Letters Pub Date : 2024-11-14 DOI:10.1016/j.ccr.2024.216330

Fereshte Hassanzadeh Afruzi, Majid Abdouss, Ehsan Nazarzadeh Zare, Erfan Rezvani Ghomi, Shima Mahmoudi, Rasoul Esmaeely Neisiany

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Abstract

Wound healing remains a significant global healthcare challenge, particularly for chronic and complex wounds, imposing the development of advanced therapeutic materials with improved functionality and efficacy. The emergence of hybrid and composite materials offers promising solutions to the multifaceted challenges of wound healing, including infection control and tissue regeneration. Metal-organic frameworks (MOFs) have gained attention due to their high porosity, large surface areas, structural tunability, and potential to incorporate therapeutic agents, making them ideal candidates for wound healing applications. Additionally, hydrogels are recognized for their soft, porous, extracellular matrix-like structure, moisturizing properties, and biocompatibility, which make them valuable in wound care. The integration of MOFs with hydrogels creates synergistic hybrid systems that combine the exceptional cargo-loading capacity and controllable degradation of MOFs with the biocompatibility and moisture-retention properties of hydrogels. This results in enhanced wound healing potential compared to the individual components. This article overviews the wound healing process and current therapeutic challenges, surveys the biomedical applications of MOFs and hydrogels individually, and presents their preparation methods. A detailed analysis of MOF-hydrogel composites (MOF-HCs) is provided including their functionality, wound-healing mechanisms, closure capabilities, and biocompatibility. This article also offers critical insights, supported by a thorough review of current research. Finally, the existing challenges and proposed future directions are highlighted, offering valuable perspectives for researchers in the field.

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金属有机框架-水凝胶复合材料作为增强伤口愈合应用的新兴平台：材料设计、治疗策略与未来前景

伤口愈合仍然是全球医疗保健领域面临的重大挑战，尤其是对于慢性和复杂伤口而言，这就要求开发功能更强、疗效更好的先进治疗材料。混合材料和复合材料的出现为应对伤口愈合的多方面挑战（包括感染控制和组织再生）提供了前景广阔的解决方案。金属有机框架（MOFs）因其孔隙率高、比表面积大、结构可调以及具有结合治疗剂的潜力而备受关注，成为伤口愈合应用的理想候选材料。此外，水凝胶因其柔软、多孔、类似细胞外基质的结构、保湿特性和生物相容性而得到认可，这使其在伤口护理方面具有重要价值。MOFs 与水凝胶的结合产生了协同混合系统，将 MOFs 卓越的载货能力和可控降解与水凝胶的生物相容性和保湿特性结合在一起。与单个成分相比，它能增强伤口愈合潜力。本文概述了伤口愈合过程和当前的治疗挑战，调查了 MOFs 和水凝胶各自的生物医学应用，并介绍了它们的制备方法。文章详细分析了 MOF-水凝胶复合材料（MOF-HCs），包括其功能性、伤口愈合机制、闭合能力和生物相容性。本文还通过对当前研究的全面回顾，提出了重要见解。最后，文章强调了现有的挑战和建议的未来方向，为该领域的研究人员提供了宝贵的视角。

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来源期刊

ACS Medicinal Chemistry Letters CHEMISTRY, MEDICINAL-

CiteScore

7.30

自引率

2.40%

发文量

328

审稿时长

1 months

期刊介绍： ACS Medicinal Chemistry Letters is interested in receiving manuscripts that discuss various aspects of medicinal chemistry. The journal will publish studies that pertain to a broad range of subject matter, including compound design and optimization, biological evaluation, drug delivery, imaging agents, and pharmacology of both small and large bioactive molecules. Specific areas include but are not limited to: Identification, synthesis, and optimization of lead biologically active molecules and drugs (small molecules and biologics) Biological characterization of new molecular entities in the context of drug discovery Computational, cheminformatics, and structural studies for the identification or SAR analysis of bioactive molecules, ligands and their targets, etc. Novel and improved methodologies, including radiation biochemistry, with broad application to medicinal chemistry Discovery technologies for biologically active molecules from both synthetic and natural (plant and other) sources Pharmacokinetic/pharmacodynamic studies that address mechanisms underlying drug disposition and response Pharmacogenetic and pharmacogenomic studies used to enhance drug design and the translation of medicinal chemistry into the clinic Mechanistic drug metabolism and regulation of metabolic enzyme gene expression Chemistry patents relevant to the medicinal chemistry field.