Agnese Zazio , Cora Miranda Lanza , Antonietta Stango , Giacomo Guidali , Eleonora Marcantoni , Delia Lucarelli , Serena Meloni , Nadia Bolognini , Roberta Rossi , Marta Bortoletto
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Abstract
Objectives
Patients with borderline personality disorder (pw-BPD) have decreased levels of cognitive empathy, which may be subtended by mirror-like mechanisms in the somatosensory cortices, i.e., the Tactile Mirror System (TaMS). Here, we aimed to shed light on the TaMS and empathic deficits in pw-BPD focusing on connectivity, using transcranial magnetic stimulation and electroencephalography (TMS-EEG).
Methods
After study preregistration, we collected self-report measures of empathic abilities, behavioral performance in a visuo-tactile spatial congruency task investigating TaMS activity, and TMS-evoked potentials (TEPs) from 20 pw-BPD and 20 healthy controls. TMS was delivered over the right primary somatosensory cortex (S1) during touch observation and real touch delivery.
Results
Pw-BPD reported significantly lower levels of cognitive empathy than controls and made significantly more errors in reporting the side of real touches during touch observation. Moreover, pw-BPD presented an altered connectivity pattern from S1-TEPs during touch perception and touch observation, in the last case without differences between human- and object-directed touches.
Conclusions
The results do not support a specific impairment of TaMS in pw-BPD, but reveal significant behavioral and connectivity alterations within the somatosensory network during touch processing.
Significance
The present findings temper the proposed role of the TaMS in BPD, while still highlighting the involvement of somatosensory network alterations.
期刊介绍：
As of January 1999, The journal Electroencephalography and Clinical Neurophysiology, and its two sections Electromyography and Motor Control and Evoked Potentials have amalgamated to become this journal - Clinical Neurophysiology.
Clinical Neurophysiology is the official journal of the International Federation of Clinical Neurophysiology, the Brazilian Society of Clinical Neurophysiology, the Czech Society of Clinical Neurophysiology, the Italian Clinical Neurophysiology Society and the International Society of Intraoperative Neurophysiology.The journal is dedicated to fostering research and disseminating information on all aspects of both normal and abnormal functioning of the nervous system. The key aim of the publication is to disseminate scholarly reports on the pathophysiology underlying diseases of the central and peripheral nervous system of human patients. Clinical trials that use neurophysiological measures to document change are encouraged, as are manuscripts reporting data on integrated neuroimaging of central nervous function including, but not limited to, functional MRI, MEG, EEG, PET and other neuroimaging modalities.
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