The Role of Iron in Atherosclerosis and its Association with Related Diseases.

IF 5.7 2区医学 Q1 PERIPHERAL VASCULAR DISEASE Current Atherosclerosis Reports Pub Date : 2024-11-09 DOI:10.1007/s11883-024-01251-1

Yingbo Gao, Boda Wang, Mengrui Hu, Yuhan Ma, Bin Zheng

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Abstract

Purpose of review: This review aims to elucidate the multifaceted role of iron in the pathogenesis of atherosclerosis. The primary objective is to summarize recent advances in understanding how iron contributes to atherosclerosis through various cellular mechanisms. Additionally, the review explores the therapeutic implications of targeting iron metabolism in the prevention and treatment of cardiovascular diseases.

Recent findings: A growing body of literature suggests that excess iron accelerates the progression of atherosclerosis, with the deleterious form of iron, non-transferrin-bound iron (NTBI), particularly exacerbating this process. Furthermore, iron overload has been demonstrated to play a pivotal role in endothelial cells, vascular smooth muscle cells, and macrophages, contributing to plaque instability and disease progression by promoting lipid peroxidation, oxidative stress, inflammatory responses, and ferroptosis. Iron plays a complex role in atherosclerosis, influencing multiple cellular processes and promoting disease progression. By promoting oxidative stress, inflammation, and ferroptosis, iron exacerbates endothelial dysfunction, smooth muscle cell calcification, and the formation of macrophage-derived foam cells. Targeted therapies focusing on iron metabolism have proven effective in treating atherosclerosis and other cardiovascular diseases.

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铁在动脉粥样硬化中的作用及其与相关疾病的联系。

综述的目的：本综述旨在阐明铁在动脉粥样硬化发病机制中的多方面作用。主要目的是总结最近在了解铁如何通过各种细胞机制导致动脉粥样硬化方面取得的进展。此外，该综述还探讨了针对铁代谢预防和治疗心血管疾病的治疗意义：越来越多的文献表明，过量的铁会加速动脉粥样硬化的发展，其中有害的铁形式--非转铁蛋白结合铁（NTBI）尤其会加剧这一过程。此外，铁超载已被证明在内皮细胞、血管平滑肌细胞和巨噬细胞中起着关键作用，通过促进脂质过氧化、氧化应激、炎症反应和铁变态反应，导致斑块不稳定和疾病进展。铁在动脉粥样硬化中起着复杂的作用，影响多个细胞过程并促进疾病进展。通过促进氧化应激、炎症反应和铁变态反应，铁加剧了内皮功能障碍、平滑肌细胞钙化和巨噬细胞衍生泡沫细胞的形成。事实证明，针对铁代谢的靶向疗法可有效治疗动脉粥样硬化和其他心血管疾病。

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来源期刊

Current Atherosclerosis Reports 医学-

CiteScore

9.00

自引率

3.40%

发文量

审稿时长

6-12 weeks

期刊介绍： The aim of this journal is to systematically provide expert views on current basic science and clinical advances in the field of atherosclerosis and highlight the most important developments likely to transform the field of cardiovascular prevention, diagnosis, and treatment. We accomplish this aim by appointing major authorities to serve as Section Editors who select leading experts from around the world to provide definitive reviews on key topics and papers published in the past year. We also provide supplementary reviews and commentaries from well-known figures in the field. An Editorial Board of internationally diverse members suggests topics of special interest to their country/region and ensures that topics are current and include emerging research.

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