LTT-Validity in diagnosis and therapeutical decision making of neuroborreliosis: a prospective dual-centre study.

IF 5.4 2区医学 Q1 INFECTIOUS DISEASES Infection Pub Date : 2024-11-14 DOI:10.1007/s15010-024-02437-0

G Summer, V Fingerle, A Spörl, C Lechner, T A Rupprecht

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Abstract

Objectives: The key objective of this study was to assess the validity of a commercially available in-house Lymphocyte Transformation Test (LTT) as a diagnostic parameter and indicator of disease activity/therapeutic efficacy in the context of Lyme neuroborreliosis (LNB).

Methods: A prospective dual-centre study was conducted from 05/14 - 01/18. With respect to Borrelia-LTT a comparison was made between patients suffering from confirmed acute LNB and patients being affected by inflammatory neurologic diseases, defining the control group: Bell's palsy, viral meningitis, herpes zoster, Guillain-Barré-Syndrome and Encephalomyelitis disseminate. Furthermore, we investigated the LTT within the LNB group at the time of admission and again 12 weeks (+/- one week) later - after appropriate antibiotic treatment.

Results: Cases included 15 patients with LNB and 58 participants in the control group. With regard to Borrelia-LTT we calculated a low sensitivity of 40% and a moderate specificity of 91% for LNB. Additionally, LTT-levels three months after adequate antibiotic therapy did not correlate with the therapeutic response of LNB patients.

Conclusions: The present study shows that LTT is neither appropriate for LNB detection nor suitable as a follow-up marker.

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LTT-神经源性疾病的诊断和治疗决策的有效性：一项前瞻性双中心研究。

研究目的本研究的主要目的是评估市场上销售的内部淋巴细胞转化试验（LTT）作为莱姆神经源性疾病（LNB）诊断参数和疾病活动性/疗效指标的有效性：14年5月至18年1月进行了一项前瞻性双中心研究。就鲍曼-LTT而言，将确诊为急性LNB的患者与患有炎症性神经系统疾病的患者进行比较，确定对照组：对照组包括：贝尔氏麻痹、病毒性脑膜炎、带状疱疹、格林-巴利综合征和播散性脑脊髓炎。此外，我们还调查了 LNB 组患者入院时的 LTT 以及 12 周（+/-一周）后（经过适当的抗生素治疗）的 LTT：病例包括 15 名 LNB 患者和 58 名对照组患者。我们计算出 Borrelia-LTT 对 LNB 的敏感性为 40%，特异性为 91%。此外，在充分使用抗生素治疗三个月后，LTT水平与LNB患者的治疗反应无关：本研究表明，LTT 既不适合检测 LNB，也不适合作为随访指标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Infection 医学-传染病学

CiteScore

12.50

自引率

1.30%

发文量

224

审稿时长

6-12 weeks

期刊介绍： Infection is a journal dedicated to serving as a global forum for the presentation and discussion of clinically relevant information on infectious diseases. Its primary goal is to engage readers and contributors from various regions around the world in the exchange of knowledge about the etiology, pathogenesis, diagnosis, and treatment of infectious diseases, both in outpatient and inpatient settings. The journal covers a wide range of topics, including: Etiology: The study of the causes of infectious diseases. Pathogenesis: The process by which an infectious agent causes disease. Diagnosis: The methods and techniques used to identify infectious diseases. Treatment: The medical interventions and strategies employed to treat infectious diseases. Public Health: Issues of local, regional, or international significance related to infectious diseases, including prevention, control, and management strategies. Hospital Epidemiology: The study of the spread of infectious diseases within healthcare settings and the measures to prevent nosocomial infections. In addition to these, Infection also includes a specialized "Images" section, which focuses on high-quality visual content, such as images, photographs, and microscopic slides, accompanied by brief abstracts. This section is designed to highlight the clinical and diagnostic value of visual aids in the field of infectious diseases, as many conditions present with characteristic clinical signs that can be diagnosed through inspection, and imaging and microscopy are crucial for accurate diagnosis. The journal's comprehensive approach ensures that it remains a valuable resource for healthcare professionals and researchers in the field of infectious diseases.