Post-COVID recovery is faster after an infection with the SARS-CoV-2 Omicron variant: a population-based cohort study.

IF 5.4 2区医学 Q1 INFECTIOUS DISEASES Infection Pub Date : 2024-11-18 DOI:10.1007/s15010-024-02438-z

Laura Rebecca Pfrommer, Sophie Diexer, Bianca Klee, Janka Massag, Cornelia Gottschick, Oliver Purschke, Mascha Binder, Thomas Frese, Matthias Girndt, Daniel Sedding, Jonas Rosendahl, Jessica I Hoell, Irene Moor, Michael Gekle, Christine Allwang, Florian Junne, Rafael Mikolajczyk

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Abstract

Purpose: Post-COVID-19 condition (PCC) poses a substantial burden to affected individuals, health care systems, and society as a whole. We examined factors associated with recovery from PCC, focusing on the vaccination status prior to infection and the virus variant.

Methods: Our analyses are based on the population-based cohort study for digital health research in Germany (DigiHero). Respondents who reported a SARS-CoV-2 infection and COVID-related symptoms ≥ 12 weeks post-infection were classified as having PCC. Those with ongoing PCC were followed-up in six-month intervals based on their date of infection. We used a Cox model for interval-censored data to analyze PCC recovery.

Results: Among the 4,529 respondents with PCC included in our analyses, about 26%, 19%, 36%, and 44% of those infected during dominance of the SARS-CoV-2 wildtype, Alpha, Delta, and Omicron variant had recovered one year after infection, respectively. When stratifying by virus variant, vaccination was not associated with a faster recovery. Conversely, those infected with Omicron (HR = 2.20; 95%CI: 1.96-2.48) or Delta (HR = 1.69; 95%CI: 1.43-2.01) recovered faster than those infected with the SARS-CoV-2 wildtype or Alpha strain.

Conclusion: Although the recovery from PCC is faster for the newer virus variants, still a substantial fraction of those who developed PCC after an infection with the Omicron variant report prolonged persistence of symptoms.

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感染 SARS-CoV-2 Omicron 变体后，COVID 后恢复更快：一项基于人群的队列研究。

目的：COVID-19 后病情（PCC）给患者、医疗保健系统和整个社会带来了巨大负担。我们研究了与 PCC 康复相关的因素，重点是感染前的疫苗接种情况和病毒变种：我们的分析基于德国数字健康研究的人群队列研究（DigiHero）。报告感染 SARS-CoV-2 并在感染后 12 周内出现 COVID 相关症状的受访者被归类为 PCC 患者。我们根据受访者的感染日期，每隔 6 个月对持续 PCC 的受访者进行随访。我们使用区间删失数据的 Cox 模型来分析 PCC 的恢复情况：在我们分析的 4,529 名 PCC 受访者中，在 SARS-CoV-2 野生型、Alpha、Delta 和 Omicron 变种占优势期间感染的患者中，分别有 26%、19%、36% 和 44% 在感染一年后康复。如果按病毒变异分层，接种疫苗与更快康复没有关系。相反，感染 Omicron 株（HR = 2.20；95%CI：1.96-2.48）或 Delta 株（HR = 1.69；95%CI：1.43-2.01）的患者比感染 SARS-CoV-2 野生型或 Alpha 株的患者恢复得更快：结论：尽管较新的病毒变异株从 PCC 中恢复得更快，但仍有相当一部分感染 Omicron 变种后出现 PCC 的患者报告症状持续时间较长。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Infection 医学-传染病学

CiteScore

12.50

自引率

1.30%

发文量

224

审稿时长

6-12 weeks

期刊介绍： Infection is a journal dedicated to serving as a global forum for the presentation and discussion of clinically relevant information on infectious diseases. Its primary goal is to engage readers and contributors from various regions around the world in the exchange of knowledge about the etiology, pathogenesis, diagnosis, and treatment of infectious diseases, both in outpatient and inpatient settings. The journal covers a wide range of topics, including: Etiology: The study of the causes of infectious diseases. Pathogenesis: The process by which an infectious agent causes disease. Diagnosis: The methods and techniques used to identify infectious diseases. Treatment: The medical interventions and strategies employed to treat infectious diseases. Public Health: Issues of local, regional, or international significance related to infectious diseases, including prevention, control, and management strategies. Hospital Epidemiology: The study of the spread of infectious diseases within healthcare settings and the measures to prevent nosocomial infections. In addition to these, Infection also includes a specialized "Images" section, which focuses on high-quality visual content, such as images, photographs, and microscopic slides, accompanied by brief abstracts. This section is designed to highlight the clinical and diagnostic value of visual aids in the field of infectious diseases, as many conditions present with characteristic clinical signs that can be diagnosed through inspection, and imaging and microscopy are crucial for accurate diagnosis. The journal's comprehensive approach ensures that it remains a valuable resource for healthcare professionals and researchers in the field of infectious diseases.