Anthony Tang BS, Suchet Taori BS, Nicholas Fung MD, Joao Paulo Almeida MD, PhD, Pierre-Olivier Champagne MD, PhD, Juan C. Fernandez-Miranda MD, Paul Gardner MD, Peter H. Hwang MD, Jayakar V. Nayak MD, PhD, Chirag Patel MD, Zara M. Patel MD, Maria Peris Celda MD, Carlos Pinheiro-Neto MD, PhD, Olabisi Sanusi MD, Carl Snyderman MD, MBA, Brian D. Thorp MD, Jamie J. Van Gompel MD, Georgios A. Zenonos MD, Nathan T. Zwagerman MD, Eric W. Wang MD, Mathew Geltzeiler MD, Garret Choby MD
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引用次数: 0
Abstract
Objective
Neck metastases are a poor prognostic factor in olfactory neuroblastoma (ONB). Pathologic dural invasion (pathDI) may increase the risk of neck metastases due to invasion of dural lymphatics. We aim to evaluate the prognostic value of pathDI in predicting rates of neck metastases and recurrence using a large, multicenter database of ONB patients.
Data sources
Retrospective review of a prospective, multicenter database of electronic health records of all patients who presented with ONB between 2005 and 2021 at nine tertiary academic care centers within North America.
Review methods
Clinicopathologic features including modified Kadish staging systems, margin status, treatment modalities, Hyams grading, follow-up time, and survival.
Results
Of 258 ONB patients, 189 patients met the inclusion criteria. The 10-year neck recurrence-free survival (neck-RFS) rates were 85.7% (75.6‒97.3) and 61.8% (47.9‒79.8) for patients without and with pathDI, respectively (p = 0.018). Time-to-event multivariable regression analysis found pathDI to have an odds ratios of 9.7 (95% confidence interval [CI] 1.2–80.4, p = 0.04) for neck-RFS and 9.5 for RFS at any site (95% CI 1.1–83.3, p = 0.04).
Conclusion
In multivariable analysis, the presence of pathDI appears to be the strongest predictor of neck recurrence and recurrence at any site. Future studies exploring the benefit of elective neck dissection or radiation for patients with pathDI may impact disease management.
期刊介绍：
International Forum of Allergy & Rhinologyis a peer-reviewed scientific journal, and the Official Journal of the American Rhinologic Society and the American Academy of Otolaryngic Allergy.
International Forum of Allergy Rhinology provides a forum for clinical researchers, basic scientists, clinicians, and others to publish original research and explore controversies in the medical and surgical treatment of patients with otolaryngic allergy, rhinologic, and skull base conditions. The application of current research to the management of otolaryngic allergy, rhinologic, and skull base diseases and the need for further investigation will be highlighted.
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