Triterpenoid saponins from the fruit pulp of Tetrapleura tetraptera (Fabaceae).

IF 1.9 3区化学 Q3 CHEMISTRY, APPLIED Natural Product Research Pub Date : 2024-11-09 DOI:10.1080/14786419.2024.2426072

G Fru Chi, Serab Khan, Jenifer R N Kuete, Valaire Y Matieta, Japheth O Ombito, Alfred N Tamfu, Junior F Megaptche, Melvis A Chongong, Taye B Demissie, Victor Kuete, Farzana Shaheen

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Abstract

Tetrapleura tetraptera fruit, used as spice in West Africa was studied chemically; five previously undescribed triterpenoid saponins 1-5 and four known compounds 6-9 were isolated from the n-Butanol fraction. The chemical structures of all nine isolates were determined by comprehensive analysis of HRMS, 1D & 2D NMR experiments and by comparison with data in the literature. All nine compounds were evaluated for antibacterial activity by the broth microdilution through the rapid p-iodonitrotetrazolium chloride (INT) colorimetric technique. The results showed that only compounds 5 (MIC = 64 µg/mL against P. aeruginosa and P. stuartii) and 8 (MIC = 64 µg/mL against E. coli) exhibited moderate antibacterial activity. The rest of the compounds displayed weak antibacterial activity against the tested organisms. Molecular docking studies was used to comprehend antibacterial activities.

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从四叶草（豆科植物）果肉中提取的三萜类皂甙。

研究人员对西非用作香料的 Tetrapleura tetraptera 果实进行了化学研究；从正丁醇馏分中分离出了五种以前未曾描述过的三萜类皂苷 1-5 和四种已知化合物 6-9。通过对 HRMS、1D 和 2D NMR 实验进行综合分析，并与文献数据进行比较，确定了所有九种分离物的化学结构。通过肉汤微量稀释法和快速对碘硝基氯化四氮唑（INT）比色法评估了所有九种化合物的抗菌活性。结果表明，只有化合物 5（对铜绿假单胞菌和沙门氏菌的 MIC = 64 µg/mL）和化合物 8（对大肠杆菌的 MIC = 64 µg/mL）具有中等抗菌活性。其余化合物对受试生物的抗菌活性较弱。分子对接研究用于理解抗菌活性。

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来源期刊

Natural Product Research 化学-医药化学

CiteScore

5.10

自引率

9.10%

发文量

605

审稿时长

2.1 months

期刊介绍： The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds. The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal. Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section. All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.