F. prausnitzii potentially modulates the association between citrus intake and depression.

IF 13.8 1区生物学 Q1 MICROBIOLOGY Microbiome Pub Date : 2024-11-14 DOI:10.1186/s40168-024-01961-3

Chatpol Samuthpongtorn, Allison A Chan, Wenjie Ma, Fenglei Wang, Long H Nguyen, Dong D Wang, Olivia I Okereke, Curtis Huttenhower, Andrew T Chan, Raaj S Mehta

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Abstract

Background: The gut microbiome modulates the effects of diet on host health, but it remains unclear which specific foods and microbial features interact to influence risk of depression. To understand this interplay, we leveraged decades of dietary and depression data from a longitudinal cohort of women (n = 32,427), along with fecal metagenomics and plasma metabolomics from a substudy (n = 207) nested in this cohort, as well as an independent validation cohort of men (n = 307).

Results: We report that citrus intake and its components are prospectively associated with a lower risk of depression and altered abundance of 15 gut microbial species, including enriched Faecalibacterium prausnitzii. In turn, we found a lower abundance of F. prausnitzii and its metabolic pathway, S-adenosyl-L-methionine (SAM) cycle I in participants with depression. To explore causality, we found that lower SAM production by F. prausnitzii may decrease intestinal monoamine oxidase A gene expression implicated in serotonin and dopamine synthesis.

Conclusions: These data underscore the role of diet in the prevention of depression and offer a plausible explanation for how the intestinal microbiome modulates the influence of citrus on mental health. Video Abstract.

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F. prausnitzii有可能调节柑橘摄入量与抑郁症之间的关系。

背景：肠道微生物组会调节饮食对宿主健康的影响，但目前仍不清楚哪些特定食物和微生物特征会对抑郁风险产生影响。为了了解这种相互作用，我们利用了一个女性纵向队列（n = 32,427）数十年的饮食和抑郁症数据，以及嵌套在该队列中的一个子研究（n = 207）的粪便元基因组学和血浆代谢组学数据，以及一个独立的男性验证队列（n = 307）：结果：我们发现，柑橘及其成分的摄入与抑郁风险的降低和 15 种肠道微生物丰度的改变（包括富集的普氏粪杆菌）有关。反过来，我们发现在抑郁症患者中，F. prausnitzii 及其代谢途径 S-腺苷-L-蛋氨酸（SAM）循环 I 的丰度较低。为了探究其中的因果关系，我们发现普氏野扇藻产生的较低 SAM 可能会降低肠道单胺氧化酶 A 基因的表达，而这种基因与血清素和多巴胺的合成有关联：这些数据强调了饮食在预防抑郁症中的作用，并为肠道微生物组如何调节柑橘对心理健康的影响提供了一个合理的解释。视频摘要

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来源期刊

Microbiome MICROBIOLOGY-

CiteScore

21.90

自引率

2.60%

发文量

198

审稿时长

4 weeks

期刊介绍： Microbiome is a journal that focuses on studies of microbiomes in humans, animals, plants, and the environment. It covers both natural and manipulated microbiomes, such as those in agriculture. The journal is interested in research that uses meta-omics approaches or novel bioinformatics tools and emphasizes the community/host interaction and structure-function relationship within the microbiome. Studies that go beyond descriptive omics surveys and include experimental or theoretical approaches will be considered for publication. The journal also encourages research that establishes cause and effect relationships and supports proposed microbiome functions. However, studies of individual microbial isolates/species without exploring their impact on the host or the complex microbiome structures and functions will not be considered for publication. Microbiome is indexed in BIOSIS, Current Contents, DOAJ, Embase, MEDLINE, PubMed, PubMed Central, and Science Citations Index Expanded.