{"title":"A new benzodioxole derivative from the marine-derived <i>Streptomyces</i> sp. SYPHU 0002.","authors":"Pengyun Mou, Yuan Peng, Bangyan Zhang, Pengze Wang, Xianpu Ni, Huanzhang Xia","doi":"10.1080/14786419.2024.2425058","DOIUrl":null,"url":null,"abstract":"<p><p>a new benzodioxole derivative 1,3-benzodioxole-2-one-4-<i>N</i>-methylcarboxylamide (<b>1</b>), two new natural products <i>N</i>-(aminocarbonyl)-2,3-dimethoxy-benzamide (<b>2</b>) and 2,3-dimethoxy-<i>N</i>-methylbenzamide (<b>3</b>), along with eight known compounds (<b>4</b>-<b>11</b>), were isolated from the marine-derived <i>Streptomyces</i> sp. SYPHU 0002. The structures of compounds <b>1</b>-<b>11</b> were determined through comprehensive spectroscopic analyses, including HRESIMS, 1D and 2D NMR. Compound <b>9</b> showed weak antibacterial activity against <i>Bacillus pumilus</i> with the MIC value of 64 μg mL<sup>-1</sup>.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-7"},"PeriodicalIF":1.9000,"publicationDate":"2024-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Natural Product Research","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1080/14786419.2024.2425058","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}
引用次数: 0
Abstract
a new benzodioxole derivative 1,3-benzodioxole-2-one-4-N-methylcarboxylamide (1), two new natural products N-(aminocarbonyl)-2,3-dimethoxy-benzamide (2) and 2,3-dimethoxy-N-methylbenzamide (3), along with eight known compounds (4-11), were isolated from the marine-derived Streptomyces sp. SYPHU 0002. The structures of compounds 1-11 were determined through comprehensive spectroscopic analyses, including HRESIMS, 1D and 2D NMR. Compound 9 showed weak antibacterial activity against Bacillus pumilus with the MIC value of 64 μg mL-1.
期刊介绍：
The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds.
The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal.
Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section.
All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.
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