[The role and research progress of gut microbiota in placenta-derived diseases].

Abstract

Gut microbiota plays an important role in maintaining the normal function of intestinal tract, regulating the body's immunity, metabolism and other physiological processes. In recent years, the theory that gut microbiota dysbiosis affects the disease occurrence of various organ systems through the gut-organ axis has been gradually confirmed. Placental diseases of pregnancy includes early onset preeclampsia, fetal growth restriction, etc., the pathogenesis of which is unclear, but can cause adverse pregnancy outcomes. Researches show that gut microbiota dysbiosis has a certain correlation with the occurrence of placental diseases, and its mechanism may affect the occurrence of placental diseases by regulating systemic and local placental metabolism, inflammatory response and immune response. This article reviews the research progress on the effects of maternal gut microbiota dysbiosis on the occurrence of placenta-derived diseases, and provides clues for exploring the application of gut microecology to the prevention and treatment of placenta-derived diseases.