The role of epithelial-mesenchymal transition in pulmonary fibrosis: lessons from idiopathic pulmonary fibrosis and COVID-19.

IF 8.2 2区生物学 Q1 CELL BIOLOGY Cell Communication and Signaling Pub Date : 2024-11-13 DOI:10.1186/s12964-024-01925-y

Reyhaneh Niayesh-Mehr, Mojtaba Kalantar, Giulio Bontempi, Claudia Montaldo, Saeedeh Ebrahimi, Abdolamir Allameh, Ghader Babaei, Faezeh Seif, Raffaele Strippoli

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Abstract

Despite the tremendous advancements in the knowledge of the pathophysiology and clinical aspects of SARS-CoV-2 infection, still many issues remain unanswered, especially in the long-term effects. Mounting evidence suggests that pulmonary fibrosis (PF) is one of the most severe complications associated with COVID-19. Therefore, understanding the molecular mechanisms behind its development is helpful to develop successful therapeutic strategies. Epithelial to mesenchymal transition (EMT) and its cell specific variants endothelial to mesenchymal transition (EndMT) and mesothelial to mesenchymal transition (MMT) are physio-pathologic cellular reprogramming processes induced by several infectious, inflammatory and biomechanical stimuli. Cells undergoing EMT acquire invasive, profibrogenic and proinflammatory activities by secreting several extracellular mediators. Their activity has been implicated in the pathogenesis of PF in a variety of lung disorders, including idiopathic pulmonary fibrosis (IPF) and COVID-19. Aim of this article is to provide an updated survey of the cellular and molecular mechanisms, with emphasis on EMT-related processes, implicated in the genesis of PF in IFP and COVID-19.

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上皮-间质转化在肺纤维化中的作用：特发性肺纤维化和 COVID-19 的启示。

尽管人们对 SARS-CoV-2 感染的病理生理学和临床方面的认识取得了巨大进步，但仍有许多问题尚未解决，尤其是在长期影响方面。越来越多的证据表明，肺纤维化（PF）是与 COVID-19 相关的最严重并发症之一。因此，了解肺纤维化背后的分子机制有助于制定成功的治疗策略。上皮细胞向间充质转化（EMT）及其细胞特异变体内皮细胞向间充质转化（EndMT）和间皮细胞向间充质转化（MMT）是由多种感染、炎症和生物力学刺激诱导的细胞重编程过程。发生 EMT 的细胞会分泌多种细胞外介质，从而获得侵袭性、异型性和促炎活性。它们的活动与多种肺部疾病（包括特发性肺纤维化（IPF）和 COVID-19）中 PF 的发病机制有关。本文旨在对特发性肺纤维化（IPF）和 COVID-19 中 PF 成因所涉及的细胞和分子机制进行最新研究，重点是与 EMT 相关的过程。

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来源期刊

Cell Communication and Signaling CELL BIOLOGY-

CiteScore

11.00

自引率

0.00%

发文量

180

期刊介绍： Cell Communication and Signaling (CCS) is a peer-reviewed, open-access scientific journal that focuses on cellular signaling pathways in both normal and pathological conditions. It publishes original research, reviews, and commentaries, welcoming studies that utilize molecular, morphological, biochemical, structural, and cell biology approaches. CCS also encourages interdisciplinary work and innovative models, including in silico, in vitro, and in vivo approaches, to facilitate investigations of cell signaling pathways, networks, and behavior. Starting from January 2019, CCS is proud to announce its affiliation with the International Cell Death Society. The journal now encourages submissions covering all aspects of cell death, including apoptotic and non-apoptotic mechanisms, cell death in model systems, autophagy, clearance of dying cells, and the immunological and pathological consequences of dying cells in the tissue microenvironment.