Characterisation of a continuous blender: Impact of physical properties on mass holdup behaviour

IF 4.5 2区工程技术 Q2 ENGINEERING, CHEMICAL Powder Technology Pub Date : 2024-11-12 DOI:10.1016/j.powtec.2024.120440

Hikaru Graeme Jolliffe , Maria A. Velazco-Roa , Luis Martin de Juan , Martin Prostredny , Carlota Mendez Torrecillas , Gavin Reynolds , Deborah McElhone , John Robertson

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Abstract

Continuous blenders are a key unit operation in Continuous Direct Compaction, a route to solid oral dosage forms that is receiving significant interest. Mass holdup in these blenders is a crucial variable; understanding how it is influenced by material properties, equipment configuration and process settings is key. The present work evaluated a Gericke GCM-450 blender for range of outlet weir aperture geometries (angled or horizontal), material properties (pure components and blends) and process settings (throughput and impeller speed). Results show opposing mass holdup behaviour depending on weir choice, material density and flowability, likely linked to the propensity of the material to form an inclined powder surface that matches – or does not – the chosen weir geometry. The present work underscores the need for fundamental process phenomena understanding, especially when insight is sought for how blender performance varies across multiple dimensions (throughput, impeller speed, material properties) and discrete equipment choices (weir geometry).

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连续式搅拌器的特性：物理特性对质量保持行为的影响

连续混料器是连续直接压制工艺中的一个关键单元操作，这种口服固体制剂的生产工艺正受到广泛关注。这些混料机中的容积是一个关键变量；了解材料特性、设备配置和工艺设置对容积的影响至关重要。本研究对 Gericke GCM-450 型混料机的出口堰孔几何形状（倾斜或水平）、材料特性（纯成分和混合物）和工艺设置（吞吐量和叶轮速度）进行了评估。结果表明，根据堰口的选择、材料密度和流动性的不同，保质行为也截然不同，这可能与材料倾向于形成与所选堰口几何形状相匹配或不匹配的倾斜粉末表面有关。本研究强调了了解基本工艺现象的必要性，尤其是在深入了解混料机性能如何在多个维度（产量、叶轮速度、材料特性）和离散设备选择（堰的几何形状）之间发生变化时。

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来源期刊

Powder Technology 工程技术-工程：化工

CiteScore

9.90

自引率

15.40%

发文量

1047

审稿时长

46 days

期刊介绍： Powder Technology is an International Journal on the Science and Technology of Wet and Dry Particulate Systems. Powder Technology publishes papers on all aspects of the formation of particles and their characterisation and on the study of systems containing particulate solids. No limitation is imposed on the size of the particles, which may range from nanometre scale, as in pigments or aerosols, to that of mined or quarried materials. The following list of topics is not intended to be comprehensive, but rather to indicate typical subjects which fall within the scope of the journal's interests: Formation and synthesis of particles by precipitation and other methods. Modification of particles by agglomeration, coating, comminution and attrition. Characterisation of the size, shape, surface area, pore structure and strength of particles and agglomerates (including the origins and effects of inter particle forces). Packing, failure, flow and permeability of assemblies of particles. Particle-particle interactions and suspension rheology. Handling and processing operations such as slurry flow, fluidization, pneumatic conveying. Interactions between particles and their environment, including delivery of particulate products to the body. Applications of particle technology in production of pharmaceuticals, chemicals, foods, pigments, structural, and functional materials and in environmental and energy related matters. For materials-oriented contributions we are looking for articles revealing the effect of particle/powder characteristics (size, morphology and composition, in that order) on material performance or functionality and, ideally, comparison to any industrial standard.