Efficacy of the mLab App: a randomized clinical trial for increasing HIV testing uptake using mobile technology.

IF 4.7 2区医学 Q1 COMPUTER SCIENCE, INFORMATION SYSTEMS Journal of the American Medical Informatics Association Pub Date : 2024-11-19 DOI:10.1093/jamia/ocae261

Rebecca Schnall, Thomas Foster Scherr, Lisa M Kuhns, Patrick Janulis, Haomiao Jia, Olivia R Wood, Michael Almodovar, Robert Garofalo

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Abstract

Objective: To determine the efficacy of the mLab App, a mobile-delivered HIV prevention intervention to increase HIV self-testing in MSM and TGW.

Materials and methods: This was a randomized (2:2:1) clinical trial of the efficacy the mLab App as compared to standard of care vs mailed home HIV test arm among 525 MSM and TGW aged 18-29 years to increase HIV testing.

Results: The mLab App arm participants demonstrated an increase from 35.1% reporting HIV testing in the prior 6 months compared to 88.5% at 6 months. In contrast, 28.8% of control participants reported an HIV test at baseline, which only increased to 65.1% at 6 months. In a generalized linear mixed model estimating this change and controlling for multiple observations of participants, this equated to control participants reporting a 61.2% smaller increase in HIV testing relative to mLab participants (P = .001) at 6 months. This difference was maintained at 12 months with control participants reporting an 82.6% smaller increase relative to mLab App participants (P < .001) from baseline to 12 months.

Discussion and conclusion: Findings suggest that the mLab App is well-supported, evidence-based, behavioral risk-reduction intervention for increasing HIV testing rates as compared to the standard of care, suggesting that this may be a useful behavioral risk-reduction intervention for increasing HIV testing among young MSM.

Trial registration: This trial was registered with Clinicaltrials.gov NCT03803683.

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mLab 应用程序的功效：利用移动技术提高艾滋病病毒检测接受率的随机临床试验。

目的确定 mLab 应用程序的疗效，该应用程序是一种移动艾滋病毒预防干预措施，旨在提高 MSM 和 TGW 的艾滋病毒自我检测率：这是一项随机（2:2:1）临床试验，目的是在 525 名 18-29 岁的 MSM 和 TGW 中，比较 mLab App 与标准护理和邮寄家庭 HIV 检测工具的效果，以增加 HIV 检测：结果：mLab 应用程序组的参与者在过去 6 个月中报告接受 HIV 检测的比例从 35.1%上升到 6 个月时的 88.5%。相比之下，28.8% 的对照组参与者在基线时报告进行了 HIV 检测，而在 6 个月时仅增加到 65.1%。通过广义线性混合模型对这一变化进行估算，并对参与者的多重观察结果进行控制，结果显示，对照组参与者在 6 个月时报告的 HIV 检测率比 mLab 参与者低 61.2%（P = .001）。这一差异在 12 个月时得以保持，对照组参与者的艾滋病检测率比 mLab 应用程序参与者低 82.6%（P 讨论和结论：研究结果表明，与标准护理相比，mLab 应用程序是得到充分支持的循证行为风险降低干预措施，可提高 HIV 检测率，这表明它可能是提高年轻 MSM HIV 检测率的有效行为风险降低干预措施：该试验已在 Clinicaltrials.gov NCT03803683 上注册。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of the American Medical Informatics Association 医学-计算机：跨学科应用

CiteScore

14.50

自引率

7.80%

发文量

230

审稿时长

3-8 weeks

期刊介绍： JAMIA is AMIA''s premier peer-reviewed journal for biomedical and health informatics. Covering the full spectrum of activities in the field, JAMIA includes informatics articles in the areas of clinical care, clinical research, translational science, implementation science, imaging, education, consumer health, public health, and policy. JAMIA''s articles describe innovative informatics research and systems that help to advance biomedical science and to promote health. Case reports, perspectives and reviews also help readers stay connected with the most important informatics developments in implementation, policy and education.