Wenyan Zhan, Jiameng Hu, Xiaoyun Chen, Gen Luo, Xiaoxiao Song
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引用次数: 0
Abstract
We present herein a highly efficient atroposelective synthesis of five/five-membered N-indolizinylpyrrole through the chiral phosphoric acid (CPA) catalyzed Paal-Knorr reaction of 3-aminoindolizines and 1,4-diketones. The reaction features mild reaction conditions, broad substrate scope and excellent enantioselectivity. Moreover, this method provides a facile approach to novel axially chiral indolizine-pyrrole framework.
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