Epidemiological and typing features of HPV co-infections in MSM with mpox: A hospital-based prospective study.

IF 4.7 3区医学 Q1 INFECTIOUS DISEASES Journal of Infection and Public Health Pub Date : 2024-11-07 DOI:10.1016/j.jiph.2024.102586

Tianyang Liu, Siwei Zhang, Liuqing Yang, Ling Peng, Shanshan Tang, Wanlin Li, Zengchen Liu, Xichao Zhu, Tingdan Gong, Siyu Duan, Yunyan Tang, Yao Wang, Yun Peng, Rui Li, Shiyan Feng, Chuming Chen, Mengli Cao, Siran Huang, Yang Yang, Fuxiang Wang, Hongzhou Lu, Lanlan Wei

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Abstract

Objectives: Recent mpox outbreaks highlight diverse transmission modes, with sexual behavior prominent in China's IIb strain. Nevertheless, despite HPV being a common sexually transmitted pathogen, there is a paucity of research into its coexistence and genotype distribution within this patients population.

Methods: We conducted a study at the Third People's Hospital of Shenzhen from May to September 2023. We collected information on mpox patients, including their sociodemographic and clinical characteristics. Anal swabs were collected for HPV genotyping.

Results: Among 73 MSM mpox cases, HIV positivity was 56.2 % (41/73) and HPV positivity 80.4 % (41/51). Multiple HPV infections were prevalent (56.9 %, 29/51), especially among HIV-positive (93 %, 27/29). HPV16 (29.3 %, 12/41) was the most common high-risk genotype, followed by HPV59 (26.8 %, 10/41), HPV42 (19.5 %, 8/41), HPV6 (14.6 %, 6/41), and HPV54 (14.6 %, 6/41). HPV infection was significantly associated with HIV infection (p = 0.001). Additionally, HIV infection (p = 0.001) and PCR-detected positive sites for mpox (p = 0.047) were associated with high-risk HPV infection.

Conclusions: In this study, most of the mpox patients were found to be infected with HPV, mostly with high-risk types and multiple infections. Therefore, it is strongly recommended that mpox-infected individuals intensify HPV-related screening, prevention, and treatment measures.

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患有疱疹的男男性行为者HPV合并感染的流行病学和分型特征：一项基于医院的前瞻性研究。

目的：最近暴发的人乳头瘤病毒传播模式多种多样，在中国的 IIb 株中，性行为尤为突出。然而，尽管人乳头瘤病毒是一种常见的性传播病原体，但有关该病毒在患者人群中的共存和基因型分布的研究却很少：方法：我们于 2023 年 5 月至 9 月在深圳市第三人民医院开展了一项研究。我们收集了痘病患者的信息，包括他们的社会人口学和临床特征。采集肛拭子进行HPV基因分型：结果：在 73 例 MSM mpox 患者中，HIV 阳性率为 56.2%（41/73），HPV 阳性率为 80.4%（41/51）。多重 HPV 感染普遍（56.9%，29/51），尤其是在 HIV 阳性者中（93%，27/29）。HPV16（29.3%，12/41）是最常见的高危基因型，其次是 HPV59（26.8%，10/41）、HPV42（19.5%，8/41）、HPV6（14.6%，6/41）和 HPV54（14.6%，6/41）。HPV 感染与 HIV 感染明显相关（p = 0.001）。此外，HIV 感染（p = 0.001）和 PCR 检测到的 mpox 阳性部位（p = 0.047）与高危 HPV 感染有关：本研究发现，大多数 mpox 患者都感染了 HPV，其中大部分为高危型和多重感染。因此，强烈建议水痘感染者加强与 HPV 相关的筛查、预防和治疗措施。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Infection and Public Health PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH -INFECTIOUS DISEASES

CiteScore

13.10

自引率

1.50%

发文量

203

审稿时长

96 days

期刊介绍： The Journal of Infection and Public Health, first official journal of the Saudi Arabian Ministry of National Guard Health Affairs, King Saud Bin Abdulaziz University for Health Sciences and the Saudi Association for Public Health, aims to be the foremost scientific, peer-reviewed journal encompassing infection prevention and control, microbiology, infectious diseases, public health and the application of healthcare epidemiology to the evaluation of health outcomes. The point of view of the journal is that infection and public health are closely intertwined and that advances in one area will have positive consequences on the other. The journal will be useful to all health professionals who are partners in the management of patients with communicable diseases, keeping them up to date. The journal is proud to have an international and diverse editorial board that will assist and facilitate the publication of articles that reflect a global view on infection control and public health, as well as emphasizing our focus on supporting the needs of public health practitioners. It is our aim to improve healthcare by reducing risk of infection and related adverse outcomes by critical review, selection, and dissemination of new and relevant information in the field of infection control, public health and infectious diseases in all healthcare settings and the community.