GOS enhances BDNF-mediated mammary gland development in pubertal mice via the gut-brain axis.

IF 7.8 1区生物学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY npj Biofilms and Microbiomes Pub Date : 2024-11-19 DOI:10.1038/s41522-024-00607-4

Yusong Ge, Yu Cao, Jialin Zhang, Feng Li, Jiaxin Wang, Mingyang Sun, Yuhao Liu, Xiaoyu Long, Wenjin Guo, Juxiong Liu, Shoupeng Fu

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Abstract

The "gut-brain axis" is involved in many physiological processes. However, its role in regulating mammary gland (MG) development remains unknown. In this study, we established the mice model of bilateral subdiaphragmatic vagotomy (Vago) to clarify the effects of "gut-brain axis" on MG development in pubertal mice. The results showed that Vago reduced the ratio of Lactobacillus and Bifidobacterium, neuronal excitability in the nucleus of solitary tract (NTS), and synthesis and secretion of BDNF, thereby slowing MG development. Transplanting the gut microbiota of Vago mice to recipient mice replicated these effects, and transplanting the gut microbiota of Control mice to Vago mice did not alleviate these effects. Galacto-Oligosaccharide (GOS), which up-regulates the ratio of Lactobacillus and Bifidobacterium, supplementation elevated NTS neuron excitability, synthesis and secretion of BDNF, and MG development, but Vago reversed these benefits. In conclusion, GOS enhances BDNF-mediated mammary gland development in pubertal mice via the "gut-brain axis".

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果寡糖通过肠脑轴促进青春期小鼠BDNF介导的乳腺发育。

肠脑轴 "参与了许多生理过程。然而，它在调控乳腺（MG）发育中的作用仍然未知。本研究建立了双侧膈下迷走神经切断术（Vago）小鼠模型，以阐明 "肠脑轴 "对青春期小鼠乳腺发育的影响。结果显示，Vago降低了乳酸杆菌和双歧杆菌的比例、孤束核（NTS）神经元的兴奋性以及BDNF的合成和分泌，从而减缓了MG的发育。将 Vago 小鼠的肠道微生物群移植到受体小鼠身上复制了这些效果，而将对照组小鼠的肠道微生物群移植到 Vago 小鼠身上并没有减轻这些效果。补充能上调乳酸杆菌和双歧杆菌比例的半乳寡糖（GOS）能提高 NTS 神经元的兴奋性、BDNF 的合成和分泌以及 MG 的发育，但 Vago 逆转了这些益处。总之，果寡糖可通过 "肠脑轴 "促进青春期小鼠BDNF介导的乳腺发育。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

npj Biofilms and Microbiomes Immunology and Microbiology-Microbiology

CiteScore

12.10

自引率

3.30%

发文量

审稿时长

9 weeks

期刊介绍： npj Biofilms and Microbiomes is a comprehensive platform that promotes research on biofilms and microbiomes across various scientific disciplines. The journal facilitates cross-disciplinary discussions to enhance our understanding of the biology, ecology, and communal functions of biofilms, populations, and communities. It also focuses on applications in the medical, environmental, and engineering domains. The scope of the journal encompasses all aspects of the field, ranging from cell-cell communication and single cell interactions to the microbiomes of humans, animals, plants, and natural and built environments. The journal also welcomes research on the virome, phageome, mycome, and fungome. It publishes both applied science and theoretical work. As an open access and interdisciplinary journal, its primary goal is to publish significant scientific advancements in microbial biofilms and microbiomes. The journal enables discussions that span multiple disciplines and contributes to our understanding of the social behavior of microbial biofilm populations and communities, and their impact on life, human health, and the environment.