Association between blood group antigens ABO, Rh, Kell, Kidd, Duffy and MNS and clinical forms of Chagas disease.

IF 1.9 4区医学 Q3 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2024-11-20 DOI:10.1093/trstmh/trae096

Alexandre G Vizzoni, Andréa Rodrigues da Costa, Alejandro M Hasslocher-Moreno, Mauro Felippe F Mediano, Roberto M Saraiva

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Abstract

Background: The mechanisms that determine the progression to cardiac or digestive forms of chronic Chagas disease (CD) are still unclear. We assessed the association between blood group antigens ABO, Rh, Kell, Kidd, Duffy and MNS, and chronic CD clinical forms.

Methods: Patients were included consecutively between March 2013 and April 2016. Clinical and epidemiological data were obtained from electronic medical records and interviews. Classification of CD clinical forms followed the Brazilian Consensus on CD. The ID-Gel Card technology from Bio-Rad (Diamed/Bio-Rad Latin America, MG, Brazil) was used to analyze the blood group antigens.

Results: A total of 619 adult patients (56.9% women, mean age 60±12 y) were included. Patients' clinical forms of CD were classified as follows: indeterminate 29.1%, cardiac 55.4%, digestive 5.5% and mixed 10.0%. Logistic regression analysis adjusted for age, comorbidities and time away from an endemic area revealed that the S+s- allele of the MNS blood type was associated with a lower odds of cardiac disease and that the B blood group type was associated with a higher odds of digestive disease. All other blood types did not have an association with CD clinical form.

Conclusions: Blood group systems ABO and MNS were associated with chronic CD clinical forms.

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血型抗原 ABO、Rh、Kell、Kidd、Duffy 和 MNS 与南美锥虫病临床形式之间的关系。

背景：决定慢性恰加斯病（CD）发展为心脏或消化系统疾病的机制仍不清楚。我们评估了血型抗原ABO、Rh、Kell、Kidd、Duffy和MNS与慢性恰加斯病临床形式之间的关联：方法：连续纳入 2013 年 3 月至 2016 年 4 月期间的患者。临床和流行病学数据来自电子病历和访谈。CD临床形式的分类遵循巴西CD共识。使用Bio-Rad公司（Diamed/Bio-Rad Latin America, MG, Brazil）的ID-Gel Card技术分析血型抗原：结果：共纳入 619 名成年患者（56.9% 为女性，平均年龄为 60±12 岁）。患者的 CD 临床形式分类如下：不确定型 29.1%、心脏型 55.4%、消化型 5.5%、混合型 10.0%。根据年龄、合并症和离开流行区的时间进行调整后的逻辑回归分析表明，MNS血型的S+s-等位基因与较低的心脏病发病几率相关，B血型与较高的消化系统疾病发病几率相关。所有其他血型均与 CD 临床表现无关：结论：ABO和MNS血型系统与慢性CD临床表现有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Transactions of The Royal Society of Tropical Medicine and Hygiene 医学-公共卫生、环境卫生与职业卫生

CiteScore

4.00

自引率

9.10%

发文量

115

审稿时长

4-8 weeks

期刊介绍： Transactions of the Royal Society of Tropical Medicine and Hygiene publishes authoritative and impactful original, peer-reviewed articles and reviews on all aspects of tropical medicine.