CT-Defined Coronary Artery Calcification as a Prognostic Marker for Overall Survival in Lung Cancer: A Systematic Review and Meta-analysis.

IF 3.8 2区医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Academic Radiology Pub Date : 2024-11-18 DOI:10.1016/j.acra.2024.10.046

Hans-Jonas Meyer, Andreas Wienke, Alexey Surov

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Abstract

Rationale and objectives: Coronary artery calcification (CAC) can be quantified by computed tomography (CT). It is an important predictive and prognostic imaging marker for cardiovascular disease. The prognostic role for CAC in oncological patients is provided in preliminary studies, especially in lung cancer patients. The aim of the present study was to establish the effect of CAC score on overall survival (OS) in lung cancer patients based on the published literature MATERIALS AND METHODS: Literature databases were screened for papers analyzing the association between CAC and overall survival in lung cancer patients up to June 2024. The primary endpoint of the present systematic review was the OS. Overall, seven studies were suitable for the analysis and were included.

Results: The included studies comprised 2292 patients undergoing curative treatment. The pooled hazard ratio for the association between CAC score and OS was HR= 1.42 (95% CI=(1.19; 1.69), p < 0.0001) in the univariable analysis and HR= 1.56 (95% CI=(1.25; 1.94), p < 0.0001) in the multivariable analysis. The pooled odds ratio for the association between CAC score and major cardiovascular events was OR= 1.97 (95% CI=(1.24; 3.13)], p = 0.004.

Conclusion: CT-defined CAC has a meaningful impact on overall survival and prediction of major cardiovascular events in lung cancer patients undergoing curative treatment. The sole presence of CAC on staging CT should be reported as an important prognostic marker in these patients.

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CT 定义的冠状动脉钙化是肺癌患者总生存期的预后标志：系统回顾与元分析》。

理由和目标：冠状动脉钙化（CAC）可通过计算机断层扫描（CT）进行量化。它是心血管疾病的重要预测和预后成像标记。初步研究表明，CAC 对肿瘤患者，尤其是肺癌患者有预后作用。本研究的目的是根据已发表的文献，确定 CAC 评分对肺癌患者总生存期（OS）的影响材料与方法：在文献数据库中筛选了截至 2024 年 6 月分析 CAC 与肺癌患者总生存期之间关系的论文。本系统综述的主要终点是 OS。共有七项研究适合进行分析并被纳入：结果：纳入的研究包括2292名接受根治性治疗的患者。CAC评分与OS之间的汇总危险比为HR= 1.42（95% CI=（1.19；1.69），P 结论：CAC评分与OS之间的关联性是非常重要的：CT定义的CAC对接受根治性治疗的肺癌患者的总生存期和主要心血管事件的预测有重要影响。在分期 CT 上仅出现 CAC 就应作为这些患者的重要预后指标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Academic Radiology 医学-核医学

CiteScore

7.60

自引率

10.40%

发文量

432

审稿时长

18 days

期刊介绍： Academic Radiology publishes original reports of clinical and laboratory investigations in diagnostic imaging, the diagnostic use of radioactive isotopes, computed tomography, positron emission tomography, magnetic resonance imaging, ultrasound, digital subtraction angiography, image-guided interventions and related techniques. It also includes brief technical reports describing original observations, techniques, and instrumental developments; state-of-the-art reports on clinical issues, new technology and other topics of current medical importance; meta-analyses; scientific studies and opinions on radiologic education; and letters to the Editor.