Lower prognostic nutritional index is associated with a greater decline in long-term kidney function in general population.

IF 4.4 2区医学 Q1 NUTRITION & DIETETICS Nutrition Journal Pub Date : 2024-11-21 DOI:10.1186/s12937-024-01047-8

In Ho Park, Nak Gyeong Ko, Mihyeon Jin, Yu-Ji Lee

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Abstract

Background: The prognostic nutritional index (PNI) is an integrated index of serum albumin and peripheral lymphocyte count, where low values may reflect poor nutritional status or inflammation. The long-term effect of PNI on renal function is not well known in the general population. Therefore, we investigated whether the PNI is related to renal function changes in the general population.

Methods: Data from participants who underwent a health check-up between 2002 and 2018 were retrospectively examined. PNI was computed by 10×serum albumin (g/dL) + 0.005×total lymphocyte count (per mm3). The primary exposure was PNI, divided into quintiles. The primary outcome was a 25% decline in eGFR from baseline over a 5-year follow-up period.

Results: This study included 15,437 participants (mean [standard deviation, SD] age, 43.7 [7.9] years; 46% male). The median (interquartile ranges) 5-year change of eGFR was - 5.2 (- 18.8, - 3.3) mL/min/1.73m². A total of 2,272 participants (14.7%) experienced a 25% decline in eGFR at 5 years. Compared to the highest PNI group, lower PNI groups were at greater risk for a 25% decline in eGFR; odds ratios and 95% confidence intervals were 1.42 (1.20, 1.68), 1.23 (1.04, 1.45), 1.21 (1.03, 1.43), and 1.19 (1.01, 1.40) for the first to fourth quintiles of PNI, respectively. In linear regression analyses, lower PNI groups also showed a larger decline in eGFR over 5 years compared to the highest PNI group.

Conclusions: Lower PNI was associated with a larger decline in renal function in the general population.

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在普通人群中，较低的预后营养指数与长期肾功能下降幅度较大有关。

背景：预后营养指数（PNI）是血清白蛋白和外周淋巴细胞计数的综合指数，低值可能反映营养状况不良或炎症。在普通人群中，PNI 对肾功能的长期影响尚不清楚。因此，我们研究了 PNI 是否与普通人群的肾功能变化有关：我们对 2002 年至 2018 年期间接受健康检查的参与者的数据进行了回顾性研究。PNI按10×血清白蛋白（克/分升）+0.005×总淋巴细胞计数（每立方毫米）计算。主要暴露指标为 PNI，分为五等分。主要结果是在 5 年随访期内 eGFR 从基线下降 25%：这项研究包括 15,437 名参与者（平均 [标准差，SD] 年龄为 43.7 [7.9] 岁；46% 为男性）。eGFR 5 年变化的中位数（四分位数间距）为 - 5.2 (- 18.8, - 3.3) mL/min/1.73m2。共有 2,272 名参与者（14.7%）的 eGFR 在 5 年后下降了 25%。与 PNI 最高的组别相比，PNI 较低的组别 eGFR 下降 25% 的风险更大；PNI 的第一至第四个五分位数的几率比和 95% 置信区间分别为 1.42（1.20，1.68）、1.23（1.04，1.45）、1.21（1.03，1.43）和 1.19（1.01，1.40）。在线性回归分析中，与 PNI 最高的组别相比，PNI 较低的组别在 5 年中的 eGFR 下降幅度也较大：结论：在普通人群中，PNI越低，肾功能下降幅度越大。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nutrition Journal NUTRITION & DIETETICS-

CiteScore

9.80

自引率

0.00%

发文量

审稿时长

4-8 weeks

期刊介绍： Nutrition Journal publishes surveillance, epidemiologic, and intervention research that sheds light on i) influences (e.g., familial, environmental) on eating patterns; ii) associations between eating patterns and health, and iii) strategies to improve eating patterns among populations. The journal also welcomes manuscripts reporting on the psychometric properties (e.g., validity, reliability) and feasibility of methods (e.g., for assessing dietary intake) for human nutrition research. In addition, study protocols for controlled trials and cohort studies, with an emphasis on methods for assessing dietary exposures and outcomes as well as intervention components, will be considered. Manuscripts that consider eating patterns holistically, as opposed to solely reductionist approaches that focus on specific dietary components in isolation, are encouraged. Also encouraged are papers that take a holistic or systems perspective in attempting to understand possible compensatory and differential effects of nutrition interventions. The journal does not consider animal studies. In addition to the influence of eating patterns for human health, we also invite research providing insights into the environmental sustainability of dietary practices. Again, a holistic perspective is encouraged, for example, through the consideration of how eating patterns might maximize both human and planetary health.