Polycyclic aromatics-derived benzene carboxylic acids (BPCAs) as a fast predictor of the genotoxicity of combustion particles.

IF 8.2 1区 环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES Science of the Total Environment Pub Date : 2024-12-20 Epub Date: 2024-11-23 DOI:10.1016/j.scitotenv.2024.177632
Chuxin Yao, Jiao Tang, Yangzhi Mo, Guangcai Zhong, Xiaofei Geng, Xin Yi, Qianyu Zhang, Jun Li, Huimin Ma, Shizhen Zhao, Gan Zhang
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Abstract

Polycyclic aromatic compounds (PAC) are common toxics in combustion particles. Numerous studies on health effects of PAC mixtures focused on limited compounds. It's still challenging to quantify complex PAC mixtures in combustion particles. Recently, benzene polycarboxylic acids (BPCAs) method, which involves conversion of PAC mixtures into a few BPCAs, has been used to quantify complex PAC mixtures in particles. In this study, in vitro biossays were used to evaluate the toxicity of extractable organic matter (EOM) in combustion particles. Analysis with Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS) identified ~1000 molecules, mostly aromatics (84.47 ± 5.32 %), that positively associate with the EOM toxicity (p < 0.05). We further employed BPCAs method to quantify PAC mixtures in the EOM of combustion particles, and observed the toxicity (especially genotoxicity) of EOM linearly increases with the abundance of PAC mixtures (r2: 0.68-0.89, p < 0.05), as it is shown by a data set referring to all source types including biomass burning, coal combustion and vehicle exhaust. The genotoxicity of PAC mixtures in EOM of combustion particles was estimated to be 10-13 times that of benzo[a]pyrene at the same mass concentration. Target analysis of 48 PAC was carried out, but a weaker relationship is found for the toxicity of EOM and the abundance of 48 PAC. Taken together, we suggest PAC-derived BPCAs as a fast predictor of the genotoxicity of combustion particles, which could be promising in routine monitoring of PAC pollution in the air.

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多环芳烃衍生苯羧酸(BPCAs)作为燃烧颗粒遗传毒性的快速预测指标。
多环芳香族化合物(PAC)是燃烧颗粒中常见的有毒物质。有关 PAC 混合物对健康影响的大量研究都集中在有限的化合物上。对燃烧颗粒中复杂的 PAC 混合物进行定量分析仍具有挑战性。最近,将 PAC 混合物转化为少量 BPCAs 的苯多羧酸(BPCAs)法被用于定量颗粒中的复杂 PAC 混合物。本研究采用体外生物测定法评估燃烧颗粒中可萃取有机物(EOM)的毒性。通过傅立叶变换离子回旋共振质谱(FT-ICR MS)分析,确定了约 1000 个与 EOM 毒性呈正相关的分子,其中大部分为芳香族(84.47 ± 5.32 %)(p 2:0.68-0.89,p 3:0.99)。
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来源期刊
Science of the Total Environment
Science of the Total Environment 环境科学-环境科学
CiteScore
17.60
自引率
10.20%
发文量
8726
审稿时长
2.4 months
期刊介绍: The Science of the Total Environment is an international journal dedicated to scientific research on the environment and its interaction with humanity. It covers a wide range of disciplines and seeks to publish innovative, hypothesis-driven, and impactful research that explores the entire environment, including the atmosphere, lithosphere, hydrosphere, biosphere, and anthroposphere. The journal's updated Aims & Scope emphasizes the importance of interdisciplinary environmental research with broad impact. Priority is given to studies that advance fundamental understanding and explore the interconnectedness of multiple environmental spheres. Field studies are preferred, while laboratory experiments must demonstrate significant methodological advancements or mechanistic insights with direct relevance to the environment.
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