Caenorhabditis elegans as a model host to study effects of lactic acid bacteria and functional food factors.

IF 1.4 4区 生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY Bioscience, Biotechnology, and Biochemistry Pub Date : 2024-11-22 DOI:10.1093/bbb/zbae172
Tomomi Komura, Yoshikazu Nishikawa
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Abstract

Several approaches for regulating health and disease by intestinal bacteria, bacteria isolated from food products, and food factors have been investigated; however, the molecular mechanisms underlying the interactions between these bacteria and their hosts are still unknown. Caenorhabditis elegans is a crucial model for exploring various biological phenomena and has been used in studying intestinal bacteria, mainly in the field of antiaging, anti-amyloid β activity in Alzheimer's disease, and its interaction to hosts. The nematode model is expected to be increasingly utilized for elucidating the interactions of beneficial bacteria or food factors with hosts. Herein, we review anti-aging and suppression of amyloid-β expression in a C. elegans model fed lactic acid bacteria, and our developed methods for orally administering food factors and assessing advanced glycation end products as an aging indicator.

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以秀丽隐杆线虫为模式宿主,研究乳酸菌和功能性食品因子的影响。
人们研究了肠道细菌、从食品中分离的细菌以及食品因子调节健康和疾病的几种方法;然而,这些细菌与其宿主之间相互作用的分子机制仍然未知。秀丽隐杆线虫是探索各种生物现象的重要模型,已被用于研究肠道细菌,主要涉及抗衰老、阿尔茨海默病中的抗淀粉样蛋白 β 活性及其与宿主的相互作用等领域。线虫模型有望越来越多地用于阐明有益细菌或食物因子与宿主的相互作用。在此,我们回顾了在喂食乳酸菌的线虫模型中抗衰老和抑制淀粉样蛋白-β表达的情况,以及我们开发的口服食物因子和评估作为衰老指标的高级糖化终产物的方法。
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来源期刊
Bioscience, Biotechnology, and Biochemistry
Bioscience, Biotechnology, and Biochemistry 生物-生化与分子生物学
CiteScore
3.50
自引率
0.00%
发文量
183
审稿时长
1 months
期刊介绍: Bioscience, Biotechnology, and Biochemistry publishes high-quality papers providing chemical and biological analyses of vital phenomena exhibited by animals, plants, and microorganisms, the chemical structures and functions of their products, and related matters. The Journal plays a major role in communicating to a global audience outstanding basic and applied research in all fields subsumed by the Japan Society for Bioscience, Biotechnology, and Agrochemistry (JSBBA).
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