Francesco Carraro, Margherita Aghito, Simone Dal Zilio, Heimo Wolinski, Christian J. Doonan, Bernd Nidetzky, Paolo Falcaro
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引用次数: 0
Abstract
The one‐pot synthesis of multicomponent hydrogen‐bonded organic framework (HOF) biocomposites is reported. The co‐immoblization of enzymes and magnetic nanoparticles (MNPs) into the HOF crystals yielded biocatalysts (MNPs‐enzyme@BioHOF‐1) with dynamic localization properties. Using a permanent magnet, it is possible to separate the MNPs‐enzyme@BioHOF‐1 particles from a solution. Catalase (CAT) and glucose oxidase (GOx) show increased retention of their activity when coimmobilized with MNPs. MNPs‐GOx@BioHOF‐1 biocomposites are used to prepare a proof‐of‐concept glucose microfluidic biosensor, where a magnet allow to position and keep in place the biocomposite inside a microfluidic chip. The magnetic response of these biocatalysts can pave the way for new applications for the emerging HOF biocomposites.
期刊介绍：
Small serves as an exceptional platform for both experimental and theoretical studies in fundamental and applied interdisciplinary research at the nano- and microscale. The journal offers a compelling mix of peer-reviewed Research Articles, Reviews, Perspectives, and Comments.
With a remarkable 2022 Journal Impact Factor of 13.3 (Journal Citation Reports from Clarivate Analytics, 2023), Small remains among the top multidisciplinary journals, covering a wide range of topics at the interface of materials science, chemistry, physics, engineering, medicine, and biology.
Small's readership includes biochemists, biologists, biomedical scientists, chemists, engineers, information technologists, materials scientists, physicists, and theoreticians alike.
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