Rapid wound healing with silver nanoparticle-decorated miswak-derived carbon quantum dots.

IF 2.4 3区医学 Q2 DERMATOLOGY Journal of tissue viability Pub Date : 2024-10-29 DOI:10.1016/j.jtv.2024.10.008

Esra Hacımüftüoğlu, Fatma Yesilyurt, Aynur Babagil, Ali Sefa Mendil, Hayrunnisa Nadaroglu

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Abstract

Background: Oxidants are pivotal in combating aging, cancer, and weakened immunity. Shielding the body from free radicals is crucial for an extended lifespan. The development of effective systems for this purpose is paramount. This study investigated the impact of miswak carbon quantum dots (M-CQD) on radical elimination and wound healing.

Methods: M-CQD were synthesized via a hydrothermal method using miswak water extract at 220 °C for 8 h. Chitosan-modified Ag@M-CS-CQD were produced. The characterization involved SEM, XRD, and FTIR analysis. M-CQD and Ag@M-CS-CQD emitted bluish-white light under UV excitation.

Results: At 10, 30, and 50 μg/mL, DPPH• and phosphomolybdenum complex radicals inhibited 67 %, 82 %, and 98 %, respectively, with Ag@M-CS-CQD demonstrating the highest activity. The IC₅₀ values for M-CQD and Ag@M-CS-CQD were 0.91 ± 0.010 and 1.183 ± 0.033, respectively. Ag@M-CS-CQD NPs displayed remarkable wound healing efficacy at 20 μg/L, highlighting their potential as potent antioxidants. Immunohistochemical analyzes also showed that Ag@M-CS-CQD increased TGF-β expression levels, which was associated with wound healing.

Conclusion: This eco-friendly synthesis method yielded Ag@M-CS-CQD, which exhibited robust antioxidant properties and efficacy in wound healing. This study emphasizes the potential of these nanoparticles as effective therapeutic agents.

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使用银纳米粒子装饰的 miswak 衍生碳量子点快速愈合伤口。

背景：氧化剂是对抗衰老、癌症和免疫力下降的关键因素。保护身体免受自由基的伤害对延长寿命至关重要。为此开发有效的系统至关重要。本研究调查了miswak碳量子点（M-CQD）对自由基消除和伤口愈合的影响：方法：采用水热法合成 M-CQD，使用 miswak 水提取物，在 220 °C 下加热 8 小时。表征包括 SEM、XRD 和 FTIR 分析。在紫外线激发下，M-CQD 和 Ag@M-CS-CQD 发出蓝白色光：在 10、30 和 50 μg/mL 的浓度下，DPPH 和磷钼络合物自由基的抑制率分别为 67%、82% 和 98%，其中 Ag@M-CS-CQD 的活性最高。M-CQD 和 Ag@M-CS-CQD 的 IC50 值分别为 0.91 ± 0.010 和 1.183 ± 0.033。Ag@M-CS-CQD NPs 在 20 μg/L 的浓度下显示出显著的伤口愈合功效，凸显了其作为强效抗氧化剂的潜力。免疫组化分析还显示，Ag@M-CS-CQD 增加了 TGF-β 的表达水平，这与伤口愈合有关：结论：这种生态友好型合成方法制备出的 Ag@M-CS-CQD 具有强大的抗氧化特性和伤口愈合功效。这项研究强调了这些纳米粒子作为有效治疗剂的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of tissue viability DERMATOLOGY-NURSING

CiteScore

3.80

自引率

16.00%

发文量

110

审稿时长

>12 weeks

期刊介绍： The Journal of Tissue Viability is the official publication of the Tissue Viability Society and is a quarterly journal concerned with all aspects of the occurrence and treatment of wounds, ulcers and pressure sores including patient care, pain, nutrition, wound healing, research, prevention, mobility, social problems and management. The Journal particularly encourages papers covering skin and skin wounds but will consider articles that discuss injury in any tissue. Articles that stress the multi-professional nature of tissue viability are especially welcome. We seek to encourage new authors as well as well-established contributors to the field - one aim of the journal is to enable all participants in tissue viability to share information with colleagues.