Impact of Lymphocyte/Monocyte Ratio on Outcomes in Patients with Remnant Gastric Cancer After Gastrectomy.

IF 0.9 4区医学 Q4 MEDICINE, RESEARCH & EXPERIMENTAL Yonago acta medica Pub Date : 2024-11-15 eCollection Date: 2024-11-01 DOI:10.33160/yam.2024.11.006

Shota Shimizu, Tomoyuki Matsunaga, Hiroaki Saito, Tomohiro Osaki, Kenji Fukuda, Yoji Fukumoto, Sadamu Takahashi, Kenjiro Taniguchi, Akemi Iwamoto, Hirohiko Kuroda, Kuniyuki Katano, Tomohiro Takahashi, Yu Sakano, Yuji Shishido, Kozo Miyatani, Teruhisa Sakamoto, Yoshiyuki Fujiwara

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Abstract

Background: The inflammatory response plays a crucial role in tumor development. Inflammatory markers are recognized prognostic factors in many types of cancer, including gastric cancer. However, the correlation between inflammatory markers and prognosis in remnant gastric cancer (RGC) remains unclear. The aim of this study was to evaluate the importance of inflammatory markers as a prognostic factor in patients who underwent gastrectomy for RGC.

Methods: This multicenter retrospective study involved 107 patients with RGC who underwent curative gastrectomy at 10 institutions in Japan between January 2000 and December 2016. Both overall survival (OS) and relapse-free survival (RFS) were analyzed.

Results: Receiver operating characteristic analyses indicated that the lymphocyte/monocyte ratio (LMR) had a higher area under the curve compared with other potential prognostic factors. Patients were categorized into high- and low LMR groups by the optimal LMR cutoff value. Preoperative LMR was significantly correlated with reconstruction way after the primary surgery (p=0.032) and lymphatic invasion (p=0.046). OS and RFS were significantly worse in the low- vs high LMR groups. Low LMR, T3 or deeper tumor invasion, and low body mass index were independent prognostic factors for OS and RFS.

Conclusion: Preoperative low LMR is associated with poor OS and RFS in patients who undergo gastrectomy for RGC.

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淋巴细胞/单核细胞比率对胃切除术后残余胃癌患者预后的影响

背景：炎症反应在肿瘤的发展过程中起着至关重要的作用。炎症标志物是包括胃癌在内的多种癌症的公认预后因素。然而，残胃癌（RGC）中炎症标志物与预后之间的相关性仍不清楚。本研究旨在评估炎症标志物作为RGC胃切除术患者预后因素的重要性：这项多中心回顾性研究涉及2000年1月至2016年12月期间在日本10家机构接受根治性胃切除术的107例RGC患者。研究分析了总生存期（OS）和无复发生存期（RFS）：接收者操作特征分析表明，与其他潜在预后因素相比，淋巴细胞/单核细胞比值（LMR）的曲线下面积更高。根据最佳 LMR 临界值将患者分为高 LMR 组和低 LMR 组。术前LMR与初次手术后的重建方式（P=0.032）和淋巴侵犯（P=0.046）显著相关。低LMR组与高LMR组的OS和RFS明显较差。低LMR、T3或更深的肿瘤侵犯以及低体重指数是OS和RFS的独立预后因素：结论：术前低LMR与RGC胃切除术患者较差的OS和RFS有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Yonago acta medica MEDICINE, RESEARCH & EXPERIMENTAL-

CiteScore

1.60

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Yonago Acta Medica (YAM) is an electronic journal specializing in medical sciences, published by Tottori University Medical Press, 86 Nishi-cho, Yonago 683-8503, Japan. The subject areas cover the following: molecular/cell biology; biochemistry; basic medicine; clinical medicine; veterinary medicine; clinical nutrition and food sciences; medical engineering; nursing sciences; laboratory medicine; clinical psychology; medical education. Basically, contributors are limited to members of Tottori University and Tottori University Hospital. Researchers outside the above-mentioned university community may also submit papers on the recommendation of a professor, an associate professor, or a junior associate professor at this university community. Articles are classified into four categories: review articles, original articles, patient reports, and short communications.