Down-regulated BNC1 promotes glioma by inhibiting ferroptosis via TCF21/PI3K signaling pathway BNC1TCF21PI3K

IF 2.7 4区生物学 Q1 ANATOMY & MORPHOLOGY Tissue & cell Pub Date : 2024-11-21 DOI:10.1016/j.tice.2024.102633

Tao Zhang, Long Zhao, Xiaoping Tang

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Abstract

We elucidate the role of the BNC1 gene in glioma and its potential mechanism. The expression levels of BNC1 in patients with glioma or corresponding cell lines were down-regulated. High BNC1 expression increased survival rate in patients with glioma. BNC1 gene reduced cell proliferation, and enhanced ferroptosis of glioma cells through the induction of TCF21/PI3K signaling pathway. Meanwhile, BNC1 gene could decline tumor proliferation in mice model of glioma. The ferroptosis inhibitor alleviated the impact of BNC1 on glioma ferroptosis, while the ferroptosis agonist weakened the effect of BNC1 on glioma ferroptosis. SiTCF21 also declined the effects of BNC1 on ferroptosis of glioma. The enhanced expression of TCF21 also inhibited the effect of BNC1 on ferroptosis of glioma. BNC1 protein interlinked with TCF21 protein, and bioluminescence imaging demonstrated that BNC1 enhanced TCF21 expression in the brain tissue of the mouse model of glioma. In conclusion, BNC1 reduced cell proliferation, and increased ferroptosis of glioma cells by TCF21/PI3K signaling pathway, may be a feasible strategy to treat glioma.

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下调的 BNC1 通过 TCF21/PI3K 信号通路 BNC1TCF21PI3K 抑制铁变态反应，从而促进胶质瘤的发展

我们阐明了 BNC1 基因在胶质瘤中的作用及其潜在机制。BNC1在胶质瘤患者或相应细胞系中的表达水平呈下调趋势。BNC1的高表达提高了胶质瘤患者的存活率。BNC1基因通过诱导TCF21/PI3K信号通路，减少细胞增殖，增强胶质瘤细胞的铁变态反应。同时，BNC1 基因能降低胶质瘤小鼠模型的肿瘤增殖。铁突变抑制剂减轻了BNC1对胶质瘤铁突变的影响，而铁突变激动剂则削弱了BNC1对胶质瘤铁突变的影响。SiTCF21 也降低了 BNC1 对胶质瘤铁突变的影响。TCF21 表达的增强也抑制了 BNC1 对胶质瘤铁突变的影响。BNC1蛋白与TCF21蛋白相互连接，生物发光成像显示BNC1增强了TCF21在胶质瘤小鼠模型脑组织中的表达。总之，BNC1通过TCF21/PI3K信号通路减少了胶质瘤细胞的增殖，增加了胶质瘤细胞的铁突变，可能是治疗胶质瘤的一种可行策略。

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来源期刊

Tissue & cell 医学-解剖学与形态学

CiteScore

3.90

自引率

0.00%

发文量

234

期刊介绍： Tissue and Cell is devoted to original research on the organization of cells, subcellular and extracellular components at all levels, including the grouping and interrelations of cells in tissues and organs. The journal encourages submission of ultrastructural studies that provide novel insights into structure, function and physiology of cells and tissues, in health and disease. Bioengineering and stem cells studies focused on the description of morphological and/or histological data are also welcomed. Studies investigating the effect of compounds and/or substances on structure of cells and tissues are generally outside the scope of this journal. For consideration, studies should contain a clear rationale on the use of (a) given substance(s), have a compelling morphological and structural focus and present novel incremental findings from previous literature.