{"title":"Giant miniature endplate potentials at vertebrate neuromuscular junctions: A review.","authors":"Karim A Alkadhi","doi":"10.1111/ejn.16624","DOIUrl":null,"url":null,"abstract":"<p><p>An unusually large amplitude spontaneous miniature endplate potentials (gMEPPs) occur naturally at low frequency at the vertebrate neuromuscular junction. Unlike the normal miniature endplate potentials (nMEPPs), these gMEPPs have long duration and long time to peak. More strikingly, gMEPPs seem to be independent of extracellular and intracellular Ca<sup>+2.</sup> and have a greater temperature sensitivity than nMEPPs. They are potentiated by tetrodotoxin but inhibited by acetylcholine (ACh) receptor blockers indicating ACh is the neurotransmitter responsible for gMEPPs. The frequency of gMEPPs is greatly increased in muscles weakened by various drugs, toxins or disease conditions suggesting that gMEPPs may be a part of possible neurotrophic mechanism to preserve effective neuromuscular transmission when the normal function is compromised.</p>","PeriodicalId":11993,"journal":{"name":"European Journal of Neuroscience","volume":" ","pages":""},"PeriodicalIF":2.7000,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"European Journal of Neuroscience","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1111/ejn.16624","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"NEUROSCIENCES","Score":null,"Total":0}
引用次数: 0
Abstract
An unusually large amplitude spontaneous miniature endplate potentials (gMEPPs) occur naturally at low frequency at the vertebrate neuromuscular junction. Unlike the normal miniature endplate potentials (nMEPPs), these gMEPPs have long duration and long time to peak. More strikingly, gMEPPs seem to be independent of extracellular and intracellular Ca+2. and have a greater temperature sensitivity than nMEPPs. They are potentiated by tetrodotoxin but inhibited by acetylcholine (ACh) receptor blockers indicating ACh is the neurotransmitter responsible for gMEPPs. The frequency of gMEPPs is greatly increased in muscles weakened by various drugs, toxins or disease conditions suggesting that gMEPPs may be a part of possible neurotrophic mechanism to preserve effective neuromuscular transmission when the normal function is compromised.
期刊介绍：
EJN is the journal of FENS and supports the international neuroscientific community by publishing original high quality research articles and reviews in all fields of neuroscience. In addition, to engage with issues that are of interest to the science community, we also publish Editorials, Meetings Reports and Neuro-Opinions on topics that are of current interest in the fields of neuroscience research and training in science. We have recently established a series of ‘Profiles of Women in Neuroscience’. Our goal is to provide a vehicle for publications that further the understanding of the structure and function of the nervous system in both health and disease and to provide a vehicle to engage the neuroscience community. As the official journal of FENS, profits from the journal are re-invested in the neuroscientific community through the activities of FENS.
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