Harnessing new and stable green carbon nanoprobes enables a selective and reliable approach to fluorimetric analysis of favipiravir drug in human plasma
Eman Alzahrani, Baher I. Salman, Ahmed I. Hassan, Ahmed Al-Harrasi, Adel Ehab Ibrahim, Abd-ElAziem Farouk, Mohamed A. Abdel-Lateef
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引用次数: 0
Abstract
The health crisis induced by the COVID-19 pandemic has accelerated the quest for innovative antiviral drugs. One such advancement is the authorization of favipiravir (FAR) as an antiviral medication for COVID-19 management. As a result, it is essential to develop precise and cost-effective methodologies for quantifying FAR levels in plasma samples and tablets. In this research, we describe the creation of novel, thermostable (25–80 °C) and pH (3–11) stable amine-doped carbon dots (N@CQDs using green source) produced via a single-step synthesis approach for the assessment of FAR with high quantum yield 33.84% for reduction in the consumed organic solvents. Carbon quantum dots (CQDs) have garnered significant attention in recent times due to their effectiveness as probes. Their affordability, environmentally friendly nature, and exceptional photocatalytic properties have positioned them as noteworthy substitutes for traditional luminescent methods such as fluorescent dyes and luminous derivatization. The addition of FAR significantly reduced the luminescence response of the synthesized green and stable carbon quantum dots at 515 nm. The linear graph for detection was quantified to be 5.0–200.0 ng mL−1, with a lower limit of quantitation (LOQ) of 3.85 ng mL−1. The method’s high sensitivity, thermostable, and selectivity make it suitable for use in clinical laboratories. Besides, the reusability and stability of the N@CQDs were conducted effectively for analysis of FAR.
COVID-19 大流行引发的健康危机加速了对创新抗病毒药物的探索。其中一项进展就是授权使用法非拉韦(FAR)作为抗病毒药物来治疗 COVID-19。因此,开发精确且经济有效的方法来量化血浆样本和药片中的 FAR 水平至关重要。在这项研究中,我们介绍了通过单步合成方法制备的新型、恒温(25-80 °C)和 pH 值(3-11)稳定的胺掺杂碳点(N@CQDs,使用绿色源),用于评估 FAR,其量子产率高达 33.84%,减少了有机溶剂的消耗。近年来,碳量子点(CQDs)因其作为探针的有效性而备受关注。碳量子点价格低廉、环境友好、光催化性能优异,因此成为荧光染料和发光衍生化等传统发光方法的理想替代品。加入 FAR 后,合成的绿色稳定碳量子点在 515 纳米波长处的发光响应明显降低。检测线性图为 5.0-200.0 ng mL-1,定量下限(LOQ)为 3.85 ng mL-1。该方法灵敏度高、恒温性好、选择性强,适用于临床实验室。此外,N@CQDs 的可重复使用性和稳定性在分析 FAR 中也得到了有效的验证。
Chemical PapersChemical Engineering-General Chemical Engineering
CiteScore
3.30
自引率
4.50%
发文量
590
期刊介绍:
Chemical Papers is a peer-reviewed, international journal devoted to basic and applied chemical research. It has a broad scope covering the chemical sciences, but favors interdisciplinary research and studies that bring chemistry together with other disciplines.