The role of kynurenine pathway metabolism mediated by exercise in the microbial-gut-brain axis in Alzheimer's disease.

IF 4.6 2区医学 Q1 NEUROSCIENCES Experimental Neurology Pub Date : 2024-11-25 DOI:10.1016/j.expneurol.2024.115070

Yiyang Wang, Weijia Wu, Fanqi Zeng, Xiangyuan Meng, Mei Peng, Juan Wang, Zeyu Chen, Wenfeng Liu

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Abstract

In recent years, the role of the microbiome-gut-brain axis in the pathogenesis of Alzheimer's disease (AD) has garnered increasing attention. Specifically, tryptophan metabolism via the kynurenine pathway (KP) plays a crucial regulatory role in this axis. This study reviews how exercise regulates the microbiome-gut-brain axis by influencing kynurenine pathway metabolism, thereby exerting resistance against AD. This paper also discusses how exercise positively impacts AD via the microbiome-gut-brain axis by modulating the endocrine, autonomic nervous, and immune systems. Although the specific mechanisms are not fully understood, research indicates that exercise may optimize tryptophan metabolism by promoting the growth of beneficial microbiota and inhibiting harmful microbiota, producing substances that are beneficial to the nervous system and combating AD. The aim of this review is to provide new perspectives and potential intervention strategies for the prevention and treatment of AD by exploring the links between exercise, KP and the gut-brain axis.

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运动介导的犬尿氨酸通路代谢在阿尔茨海默病的微生物-肠-脑轴中的作用。

近年来，微生物组-肠-脑轴在阿尔茨海默病（AD）发病机制中的作用日益受到关注。具体而言，通过犬尿氨酸途径（Kynurenine pathway，KP）进行的色氨酸代谢在该轴中发挥着至关重要的调节作用。本研究综述了运动如何通过影响犬尿氨酸途径代谢来调节微生物组-肠-脑轴，从而发挥抗老年痴呆症的作用。本文还讨论了运动如何通过调节内分泌、自主神经系统和免疫系统，通过微生物组-肠-脑轴对艾滋病产生积极影响。虽然具体机制尚未完全明了，但研究表明，运动可通过促进有益微生物群的生长和抑制有害微生物群来优化色氨酸代谢，产生对神经系统有益的物质，从而对抗注意力缺失症。本综述旨在通过探讨运动、KP 和肠脑轴之间的联系，为预防和治疗注意力缺失症提供新的视角和潜在的干预策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Experimental Neurology 医学-神经科学

CiteScore

10.10

自引率

3.80%

发文量

258

审稿时长

42 days

期刊介绍： Experimental Neurology, a Journal of Neuroscience Research, publishes original research in neuroscience with a particular emphasis on novel findings in neural development, regeneration, plasticity and transplantation. The journal has focused on research concerning basic mechanisms underlying neurological disorders.