Bilateral deep brain stimulation (DBS) of globus pallidus internus (GPi) for the treatment of benign hereditary chorea and other childhood onset choreas: a single-center experience.

IF 2.5 3区 医学 Q2 CLINICAL NEUROLOGY Neurosurgical Review Pub Date : 2024-11-28 DOI:10.1007/s10143-024-03124-2
Arthur R Kurzbuch, Ben Cooper, Gina Lumsdon, Nicola Idowu, Helen Gedrim, Philipa Mulholland, Volker Tronnier, Ram Kumar, Jonathan R Ellenbogen
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Abstract

Purpose: Chorea is a clinical sign characterized by involuntary, rapid, unpredictable, and irregular muscle movements that can affect various parts of the body. It can be seen in various medical conditions, both neurological and systemic, of genetic and acquired etiology. Deep brain stimulation (DBS) of the globus pallidus internus (GPi) has been used to treat various types of chorea. The aim of this study was to evaluate the efficacy of GPi DBS for chorea in pediatric patients.

Methods: The authors undertook a single-center retrospective study of all pediatric patients who underwent DBS in the period from July 2017 to April 2024 to identify those presenting with chorea.

Results: Three patients with chorea underwent bilateral posteroventral GPi DBS without surgical complications. The mean age at operation was 14.2 years (range: 1.5 years), and the mean follow-up was 49 months (range: 15 months). Two of the 3 patients experienced a positive effect on chorea with an improvement in functional status. In one patient, the pre- and postop Gross Motor Function Classification System (GMFCS) score was 4, while his Burke-Fahn-Marsden Dystonia Scale (BFMDS) score improved from 102/20 pre- to 53.5/20 postop. In the other patient the GMFCS score improved from 4 preop to 3 postop. His preop BFMDS score was not available, postop it was 83/120. In the patient who did not experience a positive effect on chorea the pre- and postop GMFCS score was 4, her BFMDS score was 84.5/120 pre- and 100/120 postop.

Conclusion: Bilateral GPi DBS can be safely administered to pediatric patients with choreiform movement disorders, and it could be an effective treatment option for managing chorea in certain patients.

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治疗良性遗传性舞蹈症和其他儿童期发病舞蹈症的双侧苍白球内肌(GPi)深部脑刺激(DBS):单中心经验。
目的:舞蹈症是一种临床症状,其特征是不自主、快速、不可预测和不规则的肌肉运动,可影响身体的各个部位。它可出现在各种疾病中,包括神经性和系统性疾病,也包括遗传性和获得性病因。对苍白球内肌(GPi)的深部脑刺激(DBS)已被用于治疗各种类型的舞蹈症。本研究旨在评估 GPi DBS 治疗儿童舞蹈症的疗效:作者对2017年7月至2024年4月期间接受DBS治疗的所有儿科患者进行了单中心回顾性研究,以确定那些出现舞蹈症的患者:3名舞蹈症患者接受了双侧腹后GPi DBS手术,未出现手术并发症。手术时的平均年龄为 14.2 岁(范围:1.5 岁),平均随访时间为 49 个月(范围:15 个月)。3 名患者中有 2 名患者的舞蹈症得到了积极的改善,功能状态得到了改善。其中一名患者术前和术后的粗大运动功能分级系统(GMFCS)评分均为 4 分,而他的伯克-法恩-马斯登肌张力障碍量表(BFMDS)评分从术前的 102/20 分提高到术后的 53.5/20 分。另一名患者的GMFCS评分从术前的4分提高到术后的3分。他的术前 BFMDS 评分不详,术后为 83/120。对舞蹈症没有积极影响的患者术前和术后的GMFCS评分均为4分,她的BFMDS评分为术前84.5/120,术后100/120:结论:双侧 GPi DBS 可以安全地用于患有舞蹈运动障碍的儿科患者,对于某些患者来说,它可能是控制舞蹈症的有效治疗方案。
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来源期刊
Neurosurgical Review
Neurosurgical Review 医学-临床神经学
CiteScore
5.60
自引率
7.10%
发文量
191
审稿时长
6-12 weeks
期刊介绍: The goal of Neurosurgical Review is to provide a forum for comprehensive reviews on current issues in neurosurgery. Each issue contains up to three reviews, reflecting all important aspects of one topic (a disease or a surgical approach). Comments by a panel of experts within the same issue complete the topic. By providing comprehensive coverage of one topic per issue, Neurosurgical Review combines the topicality of professional journals with the indepth treatment of a monograph. Original papers of high quality are also welcome.
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