The impact of sleep deprivation on the functional connectivity of visual-related brain regions

IF 3.4 2区医学 Q1 CLINICAL NEUROLOGY Sleep medicine Pub Date : 2024-11-22 DOI:10.1016/j.sleep.2024.11.026

Xiechuan Weng , Kai Wen , Jin Guo , Peng Zhang , Yixin Zhang , Qiongfang Cao , Qin Han , Fan Xu

{"title":"The impact of sleep deprivation on the functional connectivity of visual-related brain regions","authors":"Xiechuan Weng , Kai Wen , Jin Guo , Peng Zhang , Yixin Zhang , Qiongfang Cao , Qin Han , Fan Xu","doi":"10.1016/j.sleep.2024.11.026","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><div>Sleep deprivation(SD) is known to impair cognitive function and emotional regulation, however, its specific effects on the functional connectivity of visual-related brain regions remain unclear.</div></div><div><h3>Objectives</h3><div>This study aimed to investigate the impact of 36-h acute sleep deprivation on functional connectivity in visual neural circuits and its relationship with cognitive and emotional changes.</div></div><div><h3>Methods</h3><div>Sixty healthy male participants were assessed before and after 36 h of sleep deprivation using resting-state fMRI, the Psychomotor Vigilance Task (PVT), the Epworth Sleepiness Scale (ESS), and the Profile of Mood States (POMS). Functional connectivity changes were analyzed using paired t-tests and False Discovery Rate (FDR) correction.</div></div><div><h3>Key results</h3><div>Sleep deprivation significantly altered functional connectivity between the prefrontal cortex, hippocampus, and visual processing regions. These changes correlated with slower PVT reaction times, increased subjective sleepiness (ESS), and emotional disturbances (POMS), including heightened tension and reduced self-esteem.</div></div><div><h3>Conclusions</h3><div>The findings suggest that acute sleep deprivation impairs cognitive performance and emotional regulation by changing functional connectivity in key brain regions. These results may strengthen our understanding of neurobiology of SD and its potential negative effects.</div></div>","PeriodicalId":21874,"journal":{"name":"Sleep medicine","volume":"125 ","pages":"Pages 155-167"},"PeriodicalIF":3.4000,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Sleep medicine","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S138994572400529X","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Background

Sleep deprivation(SD) is known to impair cognitive function and emotional regulation, however, its specific effects on the functional connectivity of visual-related brain regions remain unclear.

Objectives

This study aimed to investigate the impact of 36-h acute sleep deprivation on functional connectivity in visual neural circuits and its relationship with cognitive and emotional changes.

Methods

Sixty healthy male participants were assessed before and after 36 h of sleep deprivation using resting-state fMRI, the Psychomotor Vigilance Task (PVT), the Epworth Sleepiness Scale (ESS), and the Profile of Mood States (POMS). Functional connectivity changes were analyzed using paired t-tests and False Discovery Rate (FDR) correction.

Key results

Sleep deprivation significantly altered functional connectivity between the prefrontal cortex, hippocampus, and visual processing regions. These changes correlated with slower PVT reaction times, increased subjective sleepiness (ESS), and emotional disturbances (POMS), including heightened tension and reduced self-esteem.

Conclusions

The findings suggest that acute sleep deprivation impairs cognitive performance and emotional regulation by changing functional connectivity in key brain regions. These results may strengthen our understanding of neurobiology of SD and its potential negative effects.

Abstract Image

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

睡眠剥夺对视觉相关脑区功能连通性的影响

众所周知，睡眠剥夺（SD）会损害认知功能和情绪调节，然而，其对视觉相关脑区功能连接的具体影响尚不清楚。目的探讨急性睡眠剥夺36 h对大鼠视觉神经回路功能连通性的影响及其与认知和情绪变化的关系。方法采用静息状态功能磁共振成像（fMRI）、精神运动警觉性任务（PVT）、Epworth嗜睡量表（ESS）和情绪状态量表（POMS）对60名健康男性受试者进行睡眠剥夺前后36 h的评估。使用配对t检验和错误发现率（FDR）校正分析功能连接变化。主要结果：睡眠剥夺显著改变了前额皮质、海马体和视觉处理区域之间的功能连接。这些变化与PVT反应时间变慢、主观困倦（ESS）增加和情绪障碍（POMS）相关，包括紧张加剧和自尊降低。研究结果表明，急性睡眠剥夺通过改变大脑关键区域的功能连接来损害认知表现和情绪调节。这些结果可能加强我们对SD的神经生物学及其潜在的负面影响的理解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Sleep medicine 医学-临床神经学

CiteScore

8.40

自引率

6.20%

发文量

1060

审稿时长

49 days

期刊介绍： Sleep Medicine aims to be a journal no one involved in clinical sleep medicine can do without. A journal primarily focussing on the human aspects of sleep, integrating the various disciplines that are involved in sleep medicine: neurology, clinical neurophysiology, internal medicine (particularly pulmonology and cardiology), psychology, psychiatry, sleep technology, pediatrics, neurosurgery, otorhinolaryngology, and dentistry. The journal publishes the following types of articles: Reviews (also intended as a way to bridge the gap between basic sleep research and clinical relevance); Original Research Articles; Full-length articles; Brief communications; Controversies; Case reports; Letters to the Editor; Journal search and commentaries; Book reviews; Meeting announcements; Listing of relevant organisations plus web sites.