{"title":"Unlocking the genetic potential: Strategies for enhancing secondary metabolite biosynthesis in plants","authors":"Nora M. Al Aboud","doi":"10.1016/j.jssas.2024.06.004","DOIUrl":null,"url":null,"abstract":"<div><div>The majority of secondary metabolites (SMs) are derived from plant defense, and they are crucial for the research and development of novel drugs. This article is an extensive investigation of the intricate link between genes and how those relationships affect a plant’s capacity to develop secondary metabolites. Genetics, transcriptional regulation, epigenetics the study of how genetic variation governs metabolite generation, and the identification of critical genes for improving the synthesis of secondary metabolites are all included in the research. This work highlights the role of state-of-the-art tools in genetics such as CRISPR/Cas9, RNA interference, and synthetic biology that are very important for site-specific gene alteration and metabolic engineering. On the other hand, transcriptional control and its consequences for secondary metabolism can be explained by referring to the importance of transcription factors as well as epigenetic changes. Methods of fine-tuning metabolic pathways genes to elevate metabolite yields are also highlighted in this study. The article illustrates successful genetic approaches, while at the same time discussing the challenges, environmental concerns, ethical dilemmas, barriers, and future research objectives within this fast-developing field of genetics.</div></div>","PeriodicalId":17560,"journal":{"name":"Journal of the Saudi Society of Agricultural Sciences","volume":"23 8","pages":"Pages 542-554"},"PeriodicalIF":0.0000,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of the Saudi Society of Agricultural Sciences","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1658077X24000651","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"Agricultural and Biological Sciences","Score":null,"Total":0}
引用次数: 0
Abstract
The majority of secondary metabolites (SMs) are derived from plant defense, and they are crucial for the research and development of novel drugs. This article is an extensive investigation of the intricate link between genes and how those relationships affect a plant’s capacity to develop secondary metabolites. Genetics, transcriptional regulation, epigenetics the study of how genetic variation governs metabolite generation, and the identification of critical genes for improving the synthesis of secondary metabolites are all included in the research. This work highlights the role of state-of-the-art tools in genetics such as CRISPR/Cas9, RNA interference, and synthetic biology that are very important for site-specific gene alteration and metabolic engineering. On the other hand, transcriptional control and its consequences for secondary metabolism can be explained by referring to the importance of transcription factors as well as epigenetic changes. Methods of fine-tuning metabolic pathways genes to elevate metabolite yields are also highlighted in this study. The article illustrates successful genetic approaches, while at the same time discussing the challenges, environmental concerns, ethical dilemmas, barriers, and future research objectives within this fast-developing field of genetics.
期刊介绍:
Journal of the Saudi Society of Agricultural Sciences is an English language, peer-review scholarly publication which publishes research articles and critical reviews from every area of Agricultural sciences and plant science. Scope of the journal includes, Agricultural Engineering, Plant production, Plant protection, Animal science, Agricultural extension, Agricultural economics, Food science and technology, Soil and water sciences, Irrigation science and technology and environmental science (soil formation, biological classification, mapping and management of soil). Journal of the Saudi Society of Agricultural Sciences publishes 4 issues per year and is the official publication of the King Saud University and Saudi Society of Agricultural Sciences and is published by King Saud University in collaboration with Elsevier and is edited by an international group of eminent researchers.