Xueyao Huang, Bingchen Gong, Yingying Cai, Wenrong Wang, Jian An
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引用次数: 0
Abstract
Purpose: This study aimed to compare the efficacies of Femoston and Dydrogesterone therapy in patients with incomplete abortions.
Methods: Patients with incomplete abortions were included if they preferred medication over surgical intervention. The participants were categorized into three groups: the Femoston group received Femoston, the Dydrogesterone group was administered Dydrogesterone, and the control group was followed up without treatment. Basic clinical information, complete abortion success rate, and menstrual recovery rate were collected to evaluate the efficacy of Femoston and Dydrogesterone in patients with incomplete abortions.
Results: We analyzed 332 patients with incomplete abortions. The success rate of complete abortion was significantly higher in the Femoston group than in the control group (relative risk (RR)=1.708, 95% CI 1.304-2.237, p = .001) and the Dydrogesterone group (RR = 1.200, 95% CI 1.015-1.418, p = .023). The effectiveness of Dydrogesterone was also significantly higher than that in the control group (RR = 1.439, 95% CI 1.068-1.938, p = .015). After 60 days, the rate of menstrual recovery in the Femoston group was significantly higher than that in the control group (RR =1.322, 95% CI 1.103-1.609, p = .001), while the rate in the Dydrogesterone group was significantly lower than that in the Femoston group (RR =1.200, 95% CI 1.035-1.391, p = .009).
Conclusions: Femoston and Dydrogesterone were effective in treating incomplete abortions, with Femoston being more effective. Patients receiving Femoston had shorter menstrual recovery times than those receiving dydrogesterone. Therefore, Femoston and Dydrogesterone are potential treatment options for incomplete abortion, with Femoston being the more effective.
目的：比较费莫司酮与地屈孕酮治疗不完全流产的疗效。方法：不完全流产患者选择药物治疗而非手术治疗。将参与者分为三组：费莫酮组给予费莫酮治疗，地屈孕酮组给予地屈孕酮治疗，对照组不进行治疗。收集临床基本资料、完全流产成功率、月经恢复率，评价费莫司酮和地屈孕酮在不完全流产患者中的疗效。结果：对332例不完全流产患者进行分析。费莫司酮组完全流产成功率显著高于对照组（相对危险度RR =1.708, 95% CI 1.304 ~ 2.237, p = 0.001）和地孕酮组（相对危险度RR = 1.200, 95% CI 1.015 ~ 1.418, p = 0.023）。地孕酮治疗组疗效显著高于对照组（RR = 1.439, 95% CI 1.068 ~ 1.938, p = 0.015）。60 d后，费司酮组月经恢复率显著高于对照组（RR =1.322, 95% CI 1.103 ~ 1.609, p = 0.001），地屈孕酮组月经恢复率显著低于费司酮组（RR =1.200, 95% CI 1.035 ~ 1.391, p = 0.009）。结论：费莫司酮与地屈孕酮治疗不完全流产有效，且费莫司酮效果更好。服用费莫酮的患者月经恢复时间比服用地屈孕酮的患者短。因此，费莫司酮和地屈孕酮是不完全流产的潜在治疗选择，其中费莫司酮更有效。
期刊介绍：
Gynecological Endocrinology , the official journal of the International Society of Gynecological Endocrinology, covers all the experimental, clinical and therapeutic aspects of this ever more important discipline. It includes, amongst others, papers relating to the control and function of the different endocrine glands in females, the effects of reproductive events on the endocrine system, and the consequences of endocrine disorders on reproduction
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