Modifiable Risk Factors for Cognitive Frailty in Older Chinese Patients With Diabetes: A Systematic Review and Meta-Analysis.

IF 2.1 4区医学 Q2 NURSING Research in Nursing & Health Pub Date : 2025-02-01 Epub Date: 2024-11-29 DOI:10.1002/nur.22428

Wenhui Qiu, Yixiong Zhang

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Abstract

To perform a systematic review and meta-analysis clarifying potential modifiable risk factors for cognitive frailty in older Chinese persons with diabetes. We conducted a comprehensive search across four English and four Chinese databases, spanning from 1980 to May 2024. The aim was to identify studies that investigate potential modifiable risk factors for cognitive frailty in older patients with diabetes. Meta-analysis was performed using Stata16.0. Out of the 237 records identified, 19 studies met the inclusion criteria and were consequently included for analysis. The results of the meta-analysis revealed that the prevalence of cognitive frailty among older patients with diabetes was 22.2% (95% confidence interval [CI]: 0.177-0.270, I² = 93.92%). Depression (OR = 3.18, 95% CI: 2.19-4.62, I² = 79.6%), HbA1c (OR = 2.18, 95% CI: 1.66-2.85, I² = 41.5%) and malnutrition (OR = 4.04, 95% CI: 1.58-10.34, I² = 95.0%) were significantly associated with cognitive frailty in this population. Regular exercise (OR = 0.30, 95% CI: 0.11-0.84, p < 0.01, I² = 87.3%) and higher education (OR = 0.30, 95% CI: 0.16-0.58, p < 0.01, I² = 69.7%) are identified as protective factors against cognitive frailty. This systematic review and meta-analysis demonstrates that interventions targeting depression, HbA1c level, malnutrition, exercise and education can effectively reduce the risk of cognitive frailty in older patients with diabetes.

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中国老年糖尿病患者认知衰弱的可改变危险因素：系统回顾和荟萃分析。

进行系统回顾和荟萃分析，阐明中国老年糖尿病患者认知衰弱的潜在可改变危险因素。我们对四个英文和四个中文数据库进行了全面的检索，时间跨度从1980年到2024年5月。目的是确定研究老年糖尿病患者认知衰弱的潜在可改变风险因素的研究。meta分析采用Stata16.0进行。在确定的237份记录中，有19项研究符合纳入标准，因此被纳入分析。meta分析结果显示，老年糖尿病患者的认知衰弱患病率为22.2%（95%可信区间[CI]: 0.177-0.270, I2 = 93.92%）。在该人群中，抑郁（OR = 3.18, 95% CI: 2.19-4.62, I2 = 79.6%）、糖化血红蛋白（OR = 2.18, 95% CI: 1.66-2.85, I2 = 41.5%）和营养不良（OR = 4.04, 95% CI: 1.58-10.34, I2 = 95.0%）与认知衰弱显著相关。经常运动（OR = 0.30, 95% CI: 0.11-0.84, p 2 = 87.3%）和高等教育（OR = 0.30, 95% CI: 0.16-0.58, p 2 = 69.7%）被认为是预防认知衰弱的保护因素。本系统综述和荟萃分析表明，针对抑郁、HbA1c水平、营养不良、运动和教育的干预措施可以有效降低老年糖尿病患者认知衰弱的风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Research in Nursing & Health 医学-护理

CiteScore

3.90

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Research in Nursing & Health ( RINAH ) is a peer-reviewed general research journal devoted to publication of a wide range of research that will inform the practice of nursing and other health disciplines. The editors invite reports of research describing problems and testing interventions related to health phenomena, health care and self-care, clinical organization and administration; and the testing of research findings in practice. Research protocols are considered if funded in a peer-reviewed process by an agency external to the authors’ home institution and if the work is in progress. Papers on research methods and techniques are appropriate if they go beyond what is already generally available in the literature and include description of successful use of the method. Theory papers are accepted if each proposition is supported by research evidence. Systematic reviews of the literature are reviewed if PRISMA guidelines are followed. Letters to the editor commenting on published articles are welcome.