Genetic variation among Lassa and Lassa-related arenaviruses analysed by T1-oligonucleotide mapping

J.P. Gonzalez , J.B. McCormick , M.P. Kiley
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引用次数: 5

Abstract

Total RNA and small RNA species of several African arenavirus strains have been studied by T1-oligonucleotide mapping. Genetic heterogeneity is observed and discussed on the basis of evolutionary biology of the Lassa complex.

Les ARN totaux et SARN (small RNA) de différentes souches d'arenavirus d'Afrique (complexe Lassa) et d'une souche du virus de la chorioméningite lymphocytaire de la souris, ont été comparés à l'aide de la technique de migration bidimentionnelle des oligonucléotides de restriction de la ribonucléase T1. Ces souches présentent une homologie de 76 à 86% du genome exploré. Un essai d'interprétation est proposé sur la base de la biologie évolutive de ces souches appartenant au complexe Lassa.

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用t1寡核苷酸作图分析拉沙和拉沙相关沙粒病毒的遗传变异
= =地理= =根据美国人口普查,该地区的总面积为,其中土地和(2.641平方公里)水。= =地理= =根据美国人口普查,这个县的总面积是,其中土地和(1.694平方公里)水。总RNA和SARN(小RNA)的非洲不同菌株d’arenavirus复杂(拉)和淋巴细胞性脉络丛脑膜炎病毒毒株的小鼠中,比较了使用迁移技术限制的寡核苷酸医药ribonucléase T1。这些菌株具有76 - 86%的基因组同源性。基于拉沙复合体中这些菌株的进化生物学,提出了一项解释试验。
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