Terahertz-based biosensors for biomedical applications: A review

IF 4.2 3区生物学 Q1 BIOCHEMICAL RESEARCH METHODS Methods Pub Date : 2025-02-01 DOI:10.1016/j.ymeth.2024.12.001

Meraline Selvaraj , Sreeja B S , Mohamed Aly Saad Aly

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Abstract

Biosensors have many life sciences-related applications, particularly in the healthcare sector. They are employed in a wide range of fields, including drug development, food quality management, early diagnosis of diseases, and environmental monitoring. Terahertz-based biosensing has shown great promise as a label-free, non-invasive, and non-contact method of detecting biological substances. THz Spectroscopy has achieved a remarkable advancement in biomolecule recognition providing a rapid, highly sensitive, and non-destructive approach for various biomedical applications. The significance of THz-based biosensors and the broad spectrum of biomolecules that can be detected and analyzed with biosensors are reviewed in this work. Additionally, this work summarizes several techniques that were previously reported to improve the sensitivity and selectivity of these biosensors. Furthermore, an in-depth comparison between previously developed biosensors with an emphasis on their performance is presented and highlighted in the current review. Lastly, the challenges, the potential, and the future prospects of THz-based biosensing technology are critically addressed.

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太赫兹生物医学应用生物传感器综述。

生物传感器有许多与生命科学相关的应用，特别是在医疗保健领域。他们的工作范围很广，包括药物开发、食品质量管理、疾病早期诊断和环境监测。基于太赫兹的生物传感作为一种无标签、非侵入性和非接触的检测生物物质的方法显示出巨大的前景。太赫兹光谱学在生物分子识别方面取得了显著的进步，为各种生物医学应用提供了快速、高灵敏度和非破坏性的方法。本文综述了基于太赫兹的生物传感器的意义以及生物传感器可以检测和分析的广谱生物分子。此外，本工作总结了以前报道的几种技术，以提高这些生物传感器的灵敏度和选择性。此外，深入比较了以前开发的生物传感器，重点是它们的性能，并在当前的审查中强调。最后，重点讨论了基于太赫兹的生物传感技术的挑战、潜力和未来前景。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Methods 生物-生化研究方法

CiteScore

9.80

自引率

2.10%

发文量

222

审稿时长

11.3 weeks

期刊介绍： Methods focuses on rapidly developing techniques in the experimental biological and medical sciences. Each topical issue, organized by a guest editor who is an expert in the area covered, consists solely of invited quality articles by specialist authors, many of them reviews. Issues are devoted to specific technical approaches with emphasis on clear detailed descriptions of protocols that allow them to be reproduced easily. The background information provided enables researchers to understand the principles underlying the methods; other helpful sections include comparisons of alternative methods giving the advantages and disadvantages of particular methods, guidance on avoiding potential pitfalls, and suggestions for troubleshooting.