{"title":"The people behind the papers - Roberta Azzarelli and Anna Philpott.","authors":"","doi":"10.1242/dev.204575","DOIUrl":null,"url":null,"abstract":"<p><p>ASCL1 is a pioneer factor that can reprogram somatic cells to produce neurons. Preventing ASCL1 from being phosphorylated appears to enhance its reprogramming abilities, but the reason for this is unclear. A new paper in Development explores how ASCL1 activity is affected by different cellular contexts and reveals that the basis of the reprogramming efficiency of ASCL1 is more complicated than it first appears. To learn more about the story behind the paper, we caught up with first author Roberta Azzarelli, who is now a Lecturer in Pharmacology at University College London, UK, and corresponding author Anna Philpott, Professor of Cancer and Developmental Biology at the University of Cambridge, UK.</p>","PeriodicalId":11375,"journal":{"name":"Development","volume":"151 24","pages":""},"PeriodicalIF":3.7000,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Development","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1242/dev.204575","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/12/12 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"DEVELOPMENTAL BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
ASCL1 is a pioneer factor that can reprogram somatic cells to produce neurons. Preventing ASCL1 from being phosphorylated appears to enhance its reprogramming abilities, but the reason for this is unclear. A new paper in Development explores how ASCL1 activity is affected by different cellular contexts and reveals that the basis of the reprogramming efficiency of ASCL1 is more complicated than it first appears. To learn more about the story behind the paper, we caught up with first author Roberta Azzarelli, who is now a Lecturer in Pharmacology at University College London, UK, and corresponding author Anna Philpott, Professor of Cancer and Developmental Biology at the University of Cambridge, UK.
期刊介绍：
Development’s scope covers all aspects of plant and animal development, including stem cell biology and regeneration. The single most important criterion for acceptance in Development is scientific excellence. Research papers (articles and reports) should therefore pose and test a significant hypothesis or address a significant question, and should provide novel perspectives that advance our understanding of development. We also encourage submission of papers that use computational methods or mathematical models to obtain significant new insights into developmental biology topics. Manuscripts that are descriptive in nature will be considered only when they lay important groundwork for a field and/or provide novel resources for understanding developmental processes of broad interest to the community.
Development includes a Techniques and Resources section for the publication of new methods, datasets, and other types of resources. Papers describing new techniques should include a proof-of-principle demonstration that the technique is valuable to the developmental biology community; they need not include in-depth follow-up analysis. The technique must be described in sufficient detail to be easily replicated by other investigators. Development will also consider protocol-type papers of exceptional interest to the community. We welcome submission of Resource papers, for example those reporting new databases, systems-level datasets, or genetic resources of major value to the developmental biology community. For all papers, the data or resource described must be made available to the community with minimal restrictions upon publication.
To aid navigability, Development has dedicated sections of the journal to stem cells & regeneration and to human development. The criteria for acceptance into these sections is identical to those outlined above. Authors and editors are encouraged to nominate appropriate manuscripts for inclusion in one of these sections.
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