pH-Responsive lignin-modified copper-based metal-organic frameworks for precision thiamethoxam delivery in the targeted control of red imported fire ants (Solenopsis invicta)

IF 13.3 1区 工程技术 Q1 ENGINEERING, CHEMICAL Chemical Engineering Journal Pub Date : 2025-01-01 DOI:10.1016/j.cej.2024.158644
Pengpeng Liu , Amir E. Kaziem , Chen Li , Xin Wang , Shiqi Zhu , Jinzhe Chang , Dongmei Cheng , HanHong Xu , Zhixiang Zhang , Liupeng Yang
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Abstract

The red imported fire ant (RIFA), Solenopsis invicta, is a globally invasive pest, posing a significant challenge in developing effective control strategies. HKUST-1, a classical metal–organic framework (MOF), holds potential in pest control; however, its water instability limits its practical application. In this study, we address this limitation by synthesizing lignin-modified metal–organic frameworks (L/HKUST-1), using alkaline lignin as a biopolymer carrier in a one-pot synthesis process. The effects of various temperatures, stirring speeds, and lignin concentrations on the morphology and particle size of L/HKUST-1 were systematically investigated. The resulting L/HKUST-1 exhibited an octahedral morphology with an average particle size of 530 nm, along with improved water stability and a thiamethoxam (TMX) loading rate of 26.5 %. A pH-responsive pesticide delivery system (TMX@L/HKUST-1) was developed using L/HKUST-1 as the carrier and TMX, a neonicotinoid insecticide, as the active ingredient. This system effectively controls RIFA by precisely delivering TMX in response to the acidic pH environment of the RIFA gut. In vitro release kinetics demonstrated that TMX@L/HKUST-1 rapidly releases TMX under pH 4.5 conditions. Bioassay results revealed that TMX@L/HKUST-1 significantly enhances toxicity against RIFA by increasing feeding activity and causing damage to intestinal cells. The LC50 of TMX@L/HKUST-1 was 1.225 mg/L (24 h) and 0.3164 mg/L (48 h), respectively. The system also inhibited key enzymes in detoxification and oxidative stress in RIFA. Furthermore, 16S rDNA analysis showed that TMX@L/HKUST-1 reduced the relative abundance of Serratia, while increasing the abundance of Pseudomonas and Bacillus, thereby weakening RIFA’s resistance to pesticides and pathogens. These findings suggest that TMX@L/HKUST-1 is a promising nanopesticide delivery system, offering a novel approach for the efficient control of invasive species such as RIFA.

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ph响应木质素修饰的铜基金属有机框架精准递送噻虫嗪靶向控制红火蚁(Solenopsis invicta)
红火蚁(Solenopsis invicta)是一种全球性的入侵害虫,对制定有效的防治策略提出了重大挑战。hust -1是一种经典的金属有机框架(MOF),在防治害虫方面具有潜力;但其在水中的不稳定性限制了其实际应用。在这项研究中,我们通过合成木质素修饰的金属有机框架(L/HKUST-1),利用碱性木质素作为生物聚合物载体,在一锅合成过程中解决了这一限制。系统研究了不同温度、搅拌速度和木质素浓度对L/HKUST-1的形貌和粒径的影响。得到的L/HKUST-1具有八面体形态,平均粒径为530 nm,水稳定性提高,噻虫胺(TMX)的负载率为26.5% %。以L/HKUST-1为载体,以新烟碱类杀虫剂TMX为有效成分,研制了ph响应型给药系统(TMX@L/HKUST-1)。该系统通过精确地递送TMX来响应RIFA肠道的酸性pH环境,从而有效地控制RIFA。体外释放动力学表明TMX@L/HKUST-1在pH为4.5的条件下快速释放TMX。生物测定结果显示TMX@L/HKUST-1通过提高摄食活性和引起肠细胞损伤而显著增强对RIFA的毒性。TMX@L/HKUST-1的LC50分别为1.225 mg/L (24 h)和0.3164 mg/L(48 h)。该系统还抑制了RIFA解毒和氧化应激的关键酶。此外,16S rDNA分析显示TMX@L/HKUST-1降低了沙雷氏菌的相对丰度,而增加了假单胞菌和芽孢杆菌的丰度,从而削弱了RIFA对农药和病原体的抗性。这些发现表明TMX@L/HKUST-1是一种很有前途的纳米农药递送系统,为有效控制RIFA等入侵物种提供了新的途径。
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来源期刊
Chemical Engineering Journal
Chemical Engineering Journal 工程技术-工程:化工
CiteScore
21.70
自引率
9.30%
发文量
6781
审稿时长
2.4 months
期刊介绍: The Chemical Engineering Journal is an international research journal that invites contributions of original and novel fundamental research. It aims to provide an international platform for presenting original fundamental research, interpretative reviews, and discussions on new developments in chemical engineering. The journal welcomes papers that describe novel theory and its practical application, as well as those that demonstrate the transfer of techniques from other disciplines. It also welcomes reports on carefully conducted experimental work that is soundly interpreted. The main focus of the journal is on original and rigorous research results that have broad significance. The Catalysis section within the Chemical Engineering Journal focuses specifically on Experimental and Theoretical studies in the fields of heterogeneous catalysis, molecular catalysis, and biocatalysis. These studies have industrial impact on various sectors such as chemicals, energy, materials, foods, healthcare, and environmental protection.
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