{"title":"Research advancements in the association between prevalent trace metals and connective tissue diseases.","authors":"Jie Chang, Qian Wu, Gang Wang","doi":"10.1007/s10653-024-02323-6","DOIUrl":null,"url":null,"abstract":"<p><p>Connective tissue diseases (CTD) encompass a spectrum of autoimmune disorders, including systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), Sjogren's syndrome (SS), inflammatory myopathy (IIM), systemic sclerosis (SSc), among others. Recent research has highlighted the significant role of trace metals in the pathogenesis of connective tissue diseases. This article provides an overview of recent advancements in understanding the correlation between common trace metals such as iron, copper, zinc and CTD, aiming to offer novel insights for the diagnosis and treatment of these conditions. Iron is implicated in the pathogenesis of SLE through various mechanisms, including alterations in serum iron concentration, disturbances in iron metabolism and homeostasis, as well as involvement in ferroptosis. Disorders affecting iron metabolism, ferroptosis, and the expression and regulation of associated genes and proteins contribute to the development and progression of RA. Elevated serum copper levels are observed in patients with both SLE and RA compared to healthy controls. Cuproptosis, a novel form of cell death, is also considered to be linked to their pathogenesis. Decreased serum zinc concentration is evident in patients with SLE, RA, and SS. Zinc finger proteins play a crucial role in the pathogenesis of these diseases.</p>","PeriodicalId":11759,"journal":{"name":"Environmental Geochemistry and Health","volume":"47 1","pages":"16"},"PeriodicalIF":3.2000,"publicationDate":"2024-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Environmental Geochemistry and Health","FirstCategoryId":"93","ListUrlMain":"https://doi.org/10.1007/s10653-024-02323-6","RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"ENGINEERING, ENVIRONMENTAL","Score":null,"Total":0}
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Abstract
Connective tissue diseases (CTD) encompass a spectrum of autoimmune disorders, including systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), Sjogren's syndrome (SS), inflammatory myopathy (IIM), systemic sclerosis (SSc), among others. Recent research has highlighted the significant role of trace metals in the pathogenesis of connective tissue diseases. This article provides an overview of recent advancements in understanding the correlation between common trace metals such as iron, copper, zinc and CTD, aiming to offer novel insights for the diagnosis and treatment of these conditions. Iron is implicated in the pathogenesis of SLE through various mechanisms, including alterations in serum iron concentration, disturbances in iron metabolism and homeostasis, as well as involvement in ferroptosis. Disorders affecting iron metabolism, ferroptosis, and the expression and regulation of associated genes and proteins contribute to the development and progression of RA. Elevated serum copper levels are observed in patients with both SLE and RA compared to healthy controls. Cuproptosis, a novel form of cell death, is also considered to be linked to their pathogenesis. Decreased serum zinc concentration is evident in patients with SLE, RA, and SS. Zinc finger proteins play a crucial role in the pathogenesis of these diseases.
结缔组织疾病（CTD）包括一系列自身免疫性疾病，包括系统性红斑狼疮（SLE）、类风湿性关节炎（RA）、斯约格伦综合征（SS）、炎症性肌病（IIM）、系统性硬化症（SSc）等。最新研究强调了微量金属在结缔组织疾病发病机制中的重要作用。本文概述了近期在了解铁、铜、锌等常见微量金属与结缔组织病之间的相关性方面取得的进展，旨在为这些疾病的诊断和治疗提供新的见解。铁通过各种机制与系统性红斑狼疮的发病机制有关，包括血清铁浓度的改变、铁代谢和稳态紊乱以及参与铁变态反应。影响铁代谢、铁色素沉着以及相关基因和蛋白的表达和调控的疾病会导致 RA 的发生和发展。与健康对照组相比，系统性红斑狼疮和类风湿关节炎患者的血清铜水平都会升高。铜中毒是一种新的细胞死亡形式，也被认为与这两种疾病的发病机制有关。系统性红斑狼疮、RA 和 SS 患者的血清锌浓度明显下降。锌指蛋白在这些疾病的发病机制中起着至关重要的作用。
期刊介绍：
Environmental Geochemistry and Health publishes original research papers and review papers across the broad field of environmental geochemistry. Environmental geochemistry and health establishes and explains links between the natural or disturbed chemical composition of the earth’s surface and the health of plants, animals and people.
Beneficial elements regulate or promote enzymatic and hormonal activity whereas other elements may be toxic. Bedrock geochemistry controls the composition of soil and hence that of water and vegetation. Environmental issues, such as pollution, arising from the extraction and use of mineral resources, are discussed. The effects of contaminants introduced into the earth’s geochemical systems are examined. Geochemical surveys of soil, water and plants show how major and trace elements are distributed geographically. Associated epidemiological studies reveal the possibility of causal links between the natural or disturbed geochemical environment and disease. Experimental research illuminates the nature or consequences of natural or disturbed geochemical processes.
The journal particularly welcomes novel research linking environmental geochemistry and health issues on such topics as: heavy metals (including mercury), persistent organic pollutants (POPs), and mixed chemicals emitted through human activities, such as uncontrolled recycling of electronic-waste; waste recycling; surface-atmospheric interaction processes (natural and anthropogenic emissions, vertical transport, deposition, and physical-chemical interaction) of gases and aerosols; phytoremediation/restoration of contaminated sites; food contamination and safety; environmental effects of medicines; effects and toxicity of mixed pollutants; speciation of heavy metals/metalloids; effects of mining; disturbed geochemistry from human behavior, natural or man-made hazards; particle and nanoparticle toxicology; risk and the vulnerability of populations, etc.
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