[Pooled Analysis of RET/PTC Gene Rearrangement Rate in Sporadic and Radiogenic Thyroid Papillary Carcinoma].

L N Ushenkova, A N Koterov, A P Biryukov
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Abstract

The database of publications on molecular epidemiology of RET/PTC rearrangements in sporadic and radiogenic thyroid papillary carcinoma has been formed (197 sources at the end of 2014; coverage of 100%). Based on this database a pooled analysis of data on the rates of RET/PTC1, RET/PTC3 and RET/PTC in total was conducted. Statistical approach involves a simple pooling, as well as calculations on the models of random and fixed effects. Since almost all the strata were characterized by heterogeneity, simple pooling and random effect models were adequate. Calculations using both models led to almost identical results. For rates of RET/PTC1, RET/PTC3 and RET/PTC in total with respect to formed carcinoma striations the following values (pooling, in %) were obtained: sporadic, total--13.2; 8.9; 21.2; sporadic, adults--13.3; 9.9; 21.1; sporadic, children--22.4; 17.5; 44.5; radiogenic, total--20.9; 20.3; 40.4; radiotherapy (exposure in childhood)--31.1; 11.8; 42.5; children affected after the Chernobyl accident--19.9; 23.6; 46.1; radiological incidents (exposure in adulthood)--19.9; 7.7; 18.4. Statistically proven is the reliability of differences of carcinoma indicators for children compared with adults (both sporadic and radiogenic tumors) and for radiogenic cancer compared with sporadic. The greatest increase in rate after irradiation was found for RET/PTC1, previously characterized in vitro as one of radiogenic types of RET/PTC.

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[散发性和放射源性甲状腺乳头状癌RET/PTC基因重排率的汇总分析]。
已形成散发性和放射源性甲状腺乳头状癌RET/PTC重排分子流行病学出版物数据库(截至2014年底197篇;覆盖率100%)。在此基础上,对RET/PTC1、RET/PTC3和RET/PTC总发生率数据进行汇总分析。统计方法包括简单的池化,以及随机效应和固定效应模型的计算。由于几乎所有地层都具有非均质性,因此简单的池化和随机效应模型就足够了。使用这两种模型的计算得出了几乎相同的结果。对于RET/PTC1, RET/PTC3和RET/PTC在形成癌条纹中的总发生率,我们获得了以下值(汇总,以%为单位):散发性,总-13.2;8.9;21.2;零星的成年人——13.3;9.9;21.1;零星的孩子——22.4;17.5;44.5;放射产生的总——20.9;20.3;40.4;放射治疗(儿童暴露)- 31.1;11.8;42.5;切尔诺贝利事故后受影响的儿童——19.9人;23.6;46.1;放射性事件(成年期暴露)- 19.9;7.7;18.4. 经统计证实,儿童与成人(散发性和放射源性肿瘤)以及放射源性癌症与散发性癌症的癌症指标差异的可靠性。RET/PTC1在辐照后的发病率增幅最大,此前在体外被定性为RET/PTC的一种放射源型。
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