Accurate bioaccessibility assessment of soil heavy metals by combining their speciation and in vitro model with human gut microbiota

IF 6 3区 环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES Environmental Sciences Europe Pub Date : 2024-12-19 DOI:10.1186/s12302-024-01038-w
Guofeng Li, Haifeng Chi, Yanwei Hou, Paul N. Williams, Zhao Liu, Chao Cai
{"title":"Accurate bioaccessibility assessment of soil heavy metals by combining their speciation and in vitro model with human gut microbiota","authors":"Guofeng Li,&nbsp;Haifeng Chi,&nbsp;Yanwei Hou,&nbsp;Paul N. Williams,&nbsp;Zhao Liu,&nbsp;Chao Cai","doi":"10.1186/s12302-024-01038-w","DOIUrl":null,"url":null,"abstract":"<div><p>The bioaccessibility of Zn, Ni, Cd, and Cu is a critical parameter for accurately assessing the human health risk associated with oral exposure to soils contaminated with heavy metals. However, most studies have evaluated the bioaccessibility of these metals without considering the impact of metallic chemical fractionations and human gut microbiota, which are important factors affecting the uptake of heavy metals. In this study, the bioaccessibility of Zn, Ni, Cd, and Cu in soils was measured in an improved in vitro model. The metallic chemical fractionations and bioaccessibility of heavy metals in the sterilized colon phase were also investigated. The results showed that the bioaccessibility of all four heavy metals was below 70%, indicating that relying solely on total metal concentration for assessing human health risks would result in overestimation. The exchangeable, bound to carbonates, and bound to iron and manganese fractions (F123) of heavy metals were found to be close to their bioaccessibility. Furthermore, the bioaccessibility of heavy metals in the gastric phase was strongly and positively correlated with their F123 values (r of Zn, Ni, and Cu were 0.80, 0.57, and 0.68, respectively), highlighting the close connection between metallic chemical fractionation and bioaccessibility. The bioaccessibility of Ni and Cd was found to be higher in the sterile colon phase compared to the active colon phase, whereas Cu showed lower bioaccessibility in the sterile colon phase. The significant differences in heavy metal bioaccessibility between the active and sterile colon suggested that human gut microbiota in vitro played a key role in the adsorption and desorption processes of heavy metals in the intestine. These findings underscore the importance of taking into account both metallic chemical fractionation and human gut microbiota in vitro when assessing the bioaccessibility of heavy metals and their associated health risks.</p></div>","PeriodicalId":546,"journal":{"name":"Environmental Sciences Europe","volume":"36 1","pages":""},"PeriodicalIF":6.0000,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1186/s12302-024-01038-w.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Environmental Sciences Europe","FirstCategoryId":"93","ListUrlMain":"https://link.springer.com/article/10.1186/s12302-024-01038-w","RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENVIRONMENTAL SCIENCES","Score":null,"Total":0}
引用次数: 0

Abstract

The bioaccessibility of Zn, Ni, Cd, and Cu is a critical parameter for accurately assessing the human health risk associated with oral exposure to soils contaminated with heavy metals. However, most studies have evaluated the bioaccessibility of these metals without considering the impact of metallic chemical fractionations and human gut microbiota, which are important factors affecting the uptake of heavy metals. In this study, the bioaccessibility of Zn, Ni, Cd, and Cu in soils was measured in an improved in vitro model. The metallic chemical fractionations and bioaccessibility of heavy metals in the sterilized colon phase were also investigated. The results showed that the bioaccessibility of all four heavy metals was below 70%, indicating that relying solely on total metal concentration for assessing human health risks would result in overestimation. The exchangeable, bound to carbonates, and bound to iron and manganese fractions (F123) of heavy metals were found to be close to their bioaccessibility. Furthermore, the bioaccessibility of heavy metals in the gastric phase was strongly and positively correlated with their F123 values (r of Zn, Ni, and Cu were 0.80, 0.57, and 0.68, respectively), highlighting the close connection between metallic chemical fractionation and bioaccessibility. The bioaccessibility of Ni and Cd was found to be higher in the sterile colon phase compared to the active colon phase, whereas Cu showed lower bioaccessibility in the sterile colon phase. The significant differences in heavy metal bioaccessibility between the active and sterile colon suggested that human gut microbiota in vitro played a key role in the adsorption and desorption processes of heavy metals in the intestine. These findings underscore the importance of taking into account both metallic chemical fractionation and human gut microbiota in vitro when assessing the bioaccessibility of heavy metals and their associated health risks.

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
求助全文
约1分钟内获得全文 去求助
来源期刊
Environmental Sciences Europe
Environmental Sciences Europe Environmental Science-Pollution
CiteScore
11.20
自引率
1.70%
发文量
110
审稿时长
13 weeks
期刊介绍: ESEU is an international journal, focusing primarily on Europe, with a broad scope covering all aspects of environmental sciences, including the main topic regulation. ESEU will discuss the entanglement between environmental sciences and regulation because, in recent years, there have been misunderstandings and even disagreement between stakeholders in these two areas. ESEU will help to improve the comprehension of issues between environmental sciences and regulation. ESEU will be an outlet from the German-speaking (DACH) countries to Europe and an inlet from Europe to the DACH countries regarding environmental sciences and regulation. Moreover, ESEU will facilitate the exchange of ideas and interaction between Europe and the DACH countries regarding environmental regulatory issues. Although Europe is at the center of ESEU, the journal will not exclude the rest of the world, because regulatory issues pertaining to environmental sciences can be fully seen only from a global perspective.
期刊最新文献
Accurate bioaccessibility assessment of soil heavy metals by combining their speciation and in vitro model with human gut microbiota Perfluoroalkyl and polyfluoroalkyl substances in sewage sludge: challenges of biological and thermal treatment processes and potential threats to the environment from land disposal Informing the decision-making process for potential PMT/vPvM chemicals through the adoption of a risk-based prioritization framework: the ZeroPM approach Non-extractable residues (NER) in persistence assessment: effect on the degradation half-life of chemicals Microbial pesticides: challenges and future perspectives for non-target organism testing
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1