Affinity maturation of antibody responses is mediated by differential plasma cell proliferation.

IF 44.7 1区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES Science Pub Date : 2024-12-19 DOI:10.1126/science.adr6896

Andrew J MacLean, Lachlan P Deimel, Pengcheng Zhou, Mohamed A ElTanbouly, Julia Merkenschlager, Victor Ramos, Gabriela S Santos, Thomas Hägglöf, Christian T Mayer, Brianna Hernandez, Anna Gazumyan, Michel C Nussenzweig

引用次数: 0

Abstract

Increased antibody affinity over time after vaccination, known as affinity maturation, is a prototypical feature of immune responses. Recent studies have shown that a diverse collection of B cells, producing antibodies with a wide spectrum of different affinities, are selected into the plasma cell (PC) pathway. How affinity-permissive selection enables PC affinity maturation remains unknown. We found that PC precursors (prePC) expressing high affinity antibodies received higher levels of T follicular helper (Tfh)-derived help and divided at higher rates than their lower affinity counterparts once they left the GC. Our findings indicated that differential cell division by selected prePCs accounts for how diverse precursors develop into a PC compartment that mediates serological affinity maturation.

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接种疫苗后，抗体的亲和力会随着时间的推移而增强，这被称为亲和力成熟，是免疫反应的一个典型特征。最近的研究表明，不同的 B 细胞被选入浆细胞（PC）途径，产生具有广泛不同亲和力的抗体。亲和力允许性选择如何使 PC 亲和力成熟仍是未知数。我们发现，表达高亲和力抗体的 PC 前体（prePC）一旦离开 GC，就会比亲和力较低的 PC 前体获得更高水平的 T 滤泡辅助细胞（Tfh）帮助，并以更高的速度分裂。我们的研究结果表明，被选中的前PC细胞的不同细胞分裂说明了不同的前体是如何发育成一个PC区，从而介导血清亲和力成熟的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Science 综合性期刊-综合性期刊

CiteScore

61.10

自引率

0.90%

发文量

审稿时长

2.1 months

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