Zhiyong Zhao, Ruolin Li, Yihan Wu, Mingyang Li, Dan Wu
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引用次数: 0
Abstract
Although recent studies have consistently reported the emergence of resting-state networks in early infancy, the changes in inter-network functional connectivity with age are controversial and the alterations in its dynamics remain unclear at this stage. This study aimed to investigate dynamic functional network connectivity (dFNC) using resting-state functional MRI in 244 full-term (age: 37-44 weeks) and 36 preterm infants (age: 37-43 weeks) from the dHCP dataset. We evaluated whether early dFNC exhibits age-dependent changes and is influenced by preterm birth. Gestational age (GA) and postnatal age (PNA) showed different effects on variance of FNC change over time during fMRI scan in resting-state networks, especially among high-order association networks. These variances were significantly reduced by preterm birth. Moreover, two states of weakly-connected (State Ⅰ) and strongly-connected (State Ⅱ) FNC were identified. The fraction window and dwell time in State Ⅰ, and the transition from State Ⅱ to State Ⅰ, all showed significantly negative correlations with both GA and PNA. Preterm-born infants spent a longer time in the weakly-connected state compared to term-born infants. These findings suggest a state-dependent development of dynamic FNC across brain networks in the early stages, gradually reconfiguring towards a more flexible and dynamic system with stronger connections.
期刊介绍:
The journal publishes theoretical and research papers on cognitive brain development, from infancy through childhood and adolescence and into adulthood. It covers neurocognitive development and neurocognitive processing in both typical and atypical development, including social and affective aspects. Appropriate methodologies for the journal include, but are not limited to, functional neuroimaging (fMRI and MEG), electrophysiology (EEG and ERP), NIRS and transcranial magnetic stimulation, as well as other basic neuroscience approaches using cellular and animal models that directly address cognitive brain development, patient studies, case studies, post-mortem studies and pharmacological studies.