Effects of Congestion in Human Lung Investigated Using Dual-Scale Porous Medium Models.

Abstract

Chronic obstructive pulmonary disease (COPD) is a primary chronic respiratory disease associated with pulmonary congestion that restricts airflow and thereby affects the exchange of gases between the alveoli and the blood capillaries in the lungs. Dual scale-global and local-porous medium models have been developed and reported in this work, to study the effects of air-side congestion on the blood-oxygen content in the alveolar region of the human lung. The human lung is model as a global, equivalent, heterogeneous porous medium comprising three zones with distinct permeabilities related to their progressively complex branching structure. Airflow for each breathing cycle is determined by solving mass and momentum transfer equations across the three porous medium zones. The congestion is introduced by appropriate modification of the porous medium properties of the zones considered. The congestion-affected air velocity reaching Zone 3 is given as input to a separate "local model" employed at several locations of the alveoli of Zone 3. The local model determines the oxygen content in the blood flow in the capillaries of the alveoli by solving suitable mass, momentum and species transport equations. The transient simulation results performed for a long duration of multiple breathing cycles, demonstrate that a normal, healthy human lung is functional for up to 40% volume congestion or when 50% of the lung is congested to about 23.5%. Increasing congestion beyond this value, quickly-within a few hours-depletes the oxygen exchange in the blood flow of the alveolar region (of Zone 3), leading to hypoxemia. The effects of congestion progression on oxygen exchange dynamics determined through the dual-scale porous medium modelling approach provide researchers and medical professionals with in silico predictive estimates to generate treatment strategies for chronic respiratory diseases.