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Real-Time Surgical Planning for Cerebral Aneurysms Treated With Intrasaccular Flow Disruption Devices Based on Fast Virtual Deployment and Discrete Element Method. 基于快速虚拟部署和离散元方法的脑动脉瘤实时手术规划
IF 2.2 4区 医学 Q3 ENGINEERING, BIOMEDICAL Pub Date : 2024-11-22 DOI: 10.1002/cnm.3886
Xinzhuo Li, Jiewen Geng, Yong Feng, Shengzhang Wang, Hongqi Zhang

This study introduces an innovative real-time surgical planning platform optimized for the treatment of arterial aneurysms using intrasaccular flow disruption (IFD) devices. This platform incorporates a cutting-edge fast virtual deployment (FVD) algorithm alongside a discrete element method (DEM) for computational fluid dynamics (CFD) analyses. It facilitates the efficient virtual deployment of IFD devices, minimizing computational overhead while allowing for comprehensive postoperative hemodynamic efficacy assessment. The FVD algorithm employs an adaptive wall adherence and curvature control system, validated through both idealized and patient-specific model simulations. Post-treatment hemodynamic shifts are quantified by discretizing device wire filaments into discrete particles, which are then integrated with blood flow simulations for enhanced realism. The FVD algorithm efficiently executes virtual deployment of IFD devices within seconds, producing DEM-CFD computational models that align closely with bench testing, traditional Finite Element Method (FEM) analyses, and angiographic data. DEM-CFD outcomes link occlusion effectiveness to post-implantation hemodynamic characteristics, influenced by the aneurysm's unique anatomical features and clinical intervention strategies. The proposed platform demonstrates substantial improvement in balancing computational efficiency with analytical precision. It provides a viable and innovative framework for real-time surgical planning, presenting significant implications for clinical application in arterial aneurysm management.

本研究介绍了一种创新的实时手术规划平台,该平台针对使用肌内血流阻断(IFD)装置治疗动脉动脉瘤进行了优化。该平台结合了最先进的快速虚拟部署(FVD)算法和用于计算流体动力学(CFD)分析的离散元方法(DEM)。它有助于高效虚拟部署 IFD 设备,最大限度地减少计算开销,同时进行全面的术后血液动力学疗效评估。FVD 算法采用了自适应壁粘附和曲率控制系统,并通过理想化和患者特定模型模拟进行了验证。通过将器械丝线离散成离散粒子,量化治疗后的血液动力学变化,然后将其与血流模拟集成,以增强真实感。FVD 算法可在数秒内高效执行 IFD 装置的虚拟部署,生成的 DEM-CFD 计算模型与工作台测试、传统有限元法 (FEM) 分析和血管造影数据密切吻合。DEM-CFD 的结果将闭塞效果与植入后的血流动力学特征联系起来,这些特征受到动脉瘤独特的解剖特征和临床干预策略的影响。拟议的平台在平衡计算效率和分析精度方面取得了重大改进。它为实时手术规划提供了一个可行的创新框架,对动脉瘤管理的临床应用具有重要意义。
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引用次数: 0
Analyzing Pulse Compression Performance and Image Quality Metrics of Different Excitations in MAET With Magnetic Field Measurements. 利用磁场测量分析 MAET 中不同激励的脉冲压缩性能和图像质量指标。
IF 2.2 4区 医学 Q3 ENGINEERING, BIOMEDICAL Pub Date : 2024-11-14 DOI: 10.1002/cnm.3890
Mehmet Soner Gözü, Nevzat Güneri Gençer

This study investigates the pulse compression technique to improve the performance of magneto-acousto-electrical tomography (MAET) with magnetic field measurements through numerical studies. Emphasizing the effects of specific coil configuration on MAET measurements, the study conducts evaluations using a linear phased array (LPA) transducer and numerical breast models with tumor inclusion. It provides feasibility and a detailed comparative analysis of various excitations, including linear frequency modulated (LFM), Barker code, and Golay code excitations in MAET. To simulate experimental conditions, additive White Gaussian noise is added to the MAET signal detected by the receiver coils. The results obtained from the LPA steering angle at 0° and the reconstructed B-mode MAET images using the pulse compression technique lead to improvements compared with conventional single-cycle excitation. The computed mean signal-to-noise ratio (SNR) improvements for LFM, Barker code, and Golay code excitations in B-mode MAET images for 10,000 iterations are 7.42, 8.36, and 8.44 dB, respectively, compared with single-cycle excitation. Similarly, the mean contrast-to-noise ratio (CNR) improvements for these excitations in B-mode MAET images are 1.43, 1.63, and 1.9 dB, respectively. The results demonstrate that Golay code is superior in CNR and image quality metrics, while Golay and Barker codes have comparable SNR and outperform LFM. The research shows that the coil configuration significantly impacts tumor detection. With Golay code excitation, detecting a tumor as small as 5 mm × 2 mm at a depth of 33 mm with an SNR of 6.38 dB is possible, achieving an axial resolution of 2 mm.

本研究通过数值研究探讨了脉冲压缩技术,以提高磁场测量的磁声电断层成像(MAET)性能。研究强调了特定线圈配置对 MAET 测量的影响,使用线性相控阵(LPA)传感器和包含肿瘤的乳腺数值模型进行了评估。它提供了各种激励的可行性和详细的比较分析,包括 MAET 中的线性频率调制 (LFM)、巴克编码和戈莱编码激励。为了模拟实验条件,在接收线圈检测到的 MAET 信号中加入了加性白高斯噪声。LPA 转向角为 0°,使用脉冲压缩技术重建的 B 模式 MAET 图像与传统的单周期激励相比,结果有所改进。与单周期激励相比,计算得出的 10,000 次迭代的 B 模式 MAET 图像中 LFM、Barker 码和 Golay 码激励的平均信噪比(SNR)分别提高了 7.42、8.36 和 8.44 dB。同样,这些激励在 B 模式 MAET 图像中的平均对比度-噪声比 (CNR) 分别提高了 1.43、1.63 和 1.9 dB。结果表明,Golay 码在 CNR 和图像质量指标方面更胜一筹,而 Golay 码和 Barker 码的信噪比不相上下,并优于 LFM。研究表明,线圈配置对肿瘤检测有重大影响。在戈莱码激励下,可以在 33 毫米深度检测到小至 5 毫米 × 2 毫米的肿瘤,信噪比为 6.38 dB,轴向分辨率达到 2 毫米。
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引用次数: 0
Precision Orthodontic Force Simulation Using Nodal Displacement-Based Archwire Loading Approach. 使用基于节点位移的弓丝加载法进行精确正畸力模拟
IF 2.2 4区 医学 Q3 ENGINEERING, BIOMEDICAL Pub Date : 2024-11-13 DOI: 10.1002/cnm.3889
Waheed Ahmad, Kanhui Liang, Jing Xiong, Juan Dai, Jun Cao, Zeyang Xia

Precision in force simulationis critical for forecasting tooth movement and optimizing orthodontic treatment strategies. While traditional techniques have provided valuable insights, there remains a need for improved methodologies that can seamlessly integrate with fixed orthodontic practices. This study aims to refine orthodontic force simulation techniques by integrating a nodal displacement approach within finite element analysis, specifically designed to enhance prediction accuracy in tooth movement and optimize orthodontic treatment planning. Three-dimensional patient-specific models of the Tooth, Periodontal Ligament, and Bone Complex (TPBC) of five volunteers were created, along with models of brackets and wires. The simulation involved an initial step of estimating node displacements to align the archwire with the brackets, followed by a subsequent step to attain the required tooth movement and determine the orthodontic force. Experimental validation of the simulation results was performed using an orthodontic force tester (OFT). Utilizing the nodal displacement approach, the simulation successfully positioned the archwire onto the brackets. When benchmarked against the OFT, 80% of the simulated force directions exhibited angular discrepancies of less than 5°. Additionally, the absolute differences in force magnitude reached 20.06 cN, and in moments, up to 71.76 cN mm. The relative differences were as high as 9.55% for force and 13.83% for moments. These findings represent an improvement of up to 10.45% in force accuracy and 8.87% in moment accuracy compared to median values reported in most recent literature. In this research, a nodal displacement methodology was employed to simulate orthodontic forces with precision across the dental arch. The results demonstrate the approache's potential to enhance the accuracy of force prediction in orthodontic treatment planning, thereby advancing our understanding of orthodontic biomechanics.

精确的力模拟对于预测牙齿移动和优化正畸治疗策略至关重要。虽然传统技术已经提供了有价值的见解,但仍然需要能够与固定正畸实践无缝结合的改进方法。本研究旨在通过在有限元分析中整合节点位移方法来改进正畸力模拟技术,专门用于提高牙齿移动的预测准确性和优化正畸治疗计划。研究建立了五名志愿者的牙齿、牙周韧带和骨复合体(TPBC)的三维患者特异性模型,以及托槽和钢丝模型。模拟的初始步骤是估算节点位移,以便将弓丝与托槽对齐,随后的步骤是实现所需的牙齿移动并确定矫治力。模拟结果的实验验证使用正畸力测试仪(OFT)进行。利用节点位移方法,模拟成功地将弓丝定位到托槽上。以正畸力测试仪为基准,80% 的模拟力方向显示出小于 5° 的角度差异。此外,力大小的绝对差异达到 20.06 cN,力矩的绝对差异高达 71.76 cN mm。力的相对差异高达 9.55%,力矩的相对差异高达 13.83%。这些结果表明,与最新文献报道的中值相比,力的精度提高了 10.45%,力矩的精度提高了 8.87%。在这项研究中,采用了节点位移方法来精确模拟整个牙弓的正畸力。研究结果表明,该方法有望提高正畸治疗计划中力预测的准确性,从而促进我们对正畸生物力学的理解。
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引用次数: 0
Design of Mechanics-Guided Helmet Pad and Its Protection Performance Against the Blast Shock Waves. 机械制导头盔护垫的设计及其对爆炸冲击波的防护性能。
IF 2.2 4区 医学 Q3 ENGINEERING, BIOMEDICAL Pub Date : 2024-11-12 DOI: 10.1002/cnm.3882
Zhidong Wang, Shuhuai Duan, Wenhang Liu, Yongtao Lu, Chengwei Wu, Guojun Ma

The blast shock waves generated by the explosion are severe threat to soldiers on the battlefield, while the helmets currently equipped for the soldiers cannot offer sufficient blast protection. Some helmet pads have been developed to improve the protection performance of the combat helmets against shock waves. However, it remains unclear how to design the helmet pads to protect the head more effectively against blast shock waves. This study aims to design a new mechanics-guided helmet pad and evaluate its protection performance by numerical simulations. The design of the new helmet pad is guided by the oblique reflection theory (ORT), and the advanced combat helmet (ACH) pad is applied for comparison. The protection performance of the pads against blast waves from two directions (frontal and lateral) was investigated. The differences in the distributions of overpressure inside the helmet using two types of pads were analyzed, and the intracranial pressure (ICP) of head was compared. The ORT-guided pads can reduce the overpressure inside the helmet, minimizing the possibility of blast-induced traumatic brain injury. Furthermore, the underwash phenomenon can also be controlled when the new pads are applied. The results in this study provide an important theoretical basis and some guidelines on the design of helmet pads for the protection of human brain from blast shock waves.

爆炸产生的冲击波对战场上的士兵构成严重威胁,而目前为士兵配备的头盔无法提供足够的防爆保护。为了提高作战头盔对冲击波的防护性能,人们开发了一些头盔护垫。然而,如何设计头盔衬垫以更有效地保护头部免受爆炸冲击波的伤害,目前仍不清楚。本研究旨在设计一种新型力学导向头盔垫,并通过数值模拟评估其防护性能。新型头盔护垫的设计以斜反射理论(ORT)为指导,并采用先进战斗头盔(ACH)护垫进行比较。研究了头盔垫对来自两个方向(正面和侧面)的爆炸波的防护性能。分析了使用两种衬垫时头盔内超压分布的差异,并比较了头部的颅内压(ICP)。结果表明,ORT 引导衬垫可降低头盔内的超压,最大限度地减少爆炸诱发脑外伤的可能性。此外,在使用新衬垫时,还可以控制欠冲现象。本研究的结果为保护人脑免受爆炸冲击波伤害的头盔衬垫设计提供了重要的理论依据和一些指导原则。
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引用次数: 0
Gender-Based Differences in the Biomechanical Behavior of the Thorax During CPR Maneuvers. 心肺复苏操作过程中胸廓生物力学行为的性别差异。
IF 2.2 4区 医学 Q3 ENGINEERING, BIOMEDICAL Pub Date : 2024-11-11 DOI: 10.1002/cnm.3887
María Ferrón-Vivó, María José Rupérez

In this study, 18 rib cages (8 males and 10 females) were segmented from computer tomography (CT) images. In order to analyze the potential differences in thoracic biomechanics during cardiopulmonary resuscitation (CPR), a set of numerical experiments was conducted using finite elements (FE). Compression forces were applied at different points on the rib cage. Results indicated that the optimal compression area for both sexes is the sternum at the 5th rib level, requiring the least force to achieve the desired compression depth. Males required greater force than females. Among females, those with lower width/depth ratios (more rounded thoracic shape) required less force compared to those with higher ratios (more oval-shaped thorax).

本研究从计算机断层扫描(CT)图像中分割出 18 根肋骨(8 男 10 女)。为了分析心肺复苏(CPR)过程中胸廓生物力学的潜在差异,研究人员使用有限元(FE)进行了一组数值实验。在肋骨上的不同点施加压缩力。结果表明,两性的最佳压迫区域都是第 5 肋骨水平的胸骨,需要最小的力来达到所需的压迫深度。男性比女性需要更大的力量。在女性中,宽度/深度比值较低(胸廓形状更圆)的女性所需的力量小于宽度/深度比值较高(胸廓形状更椭圆)的女性。
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引用次数: 0
Impact of Geometric Attributes on Abdominal Aortic Aneurysm Rupture Risk: An In Vivo FSI-Based Study. 几何属性对腹主动脉瘤破裂风险的影响:基于体内 FSI 的研究。
IF 2.2 4区 医学 Q3 ENGINEERING, BIOMEDICAL Pub Date : 2024-11-11 DOI: 10.1002/cnm.3884
Xiaochen Wang, Mergen H Ghayesh, Jiawen Li, Andrei Kotousov, Anthony C Zander, Joseph A Dawson, Peter J Psaltis

Reported in this paper is a cutting-edge computational investigation into the influence of geometric characteristics on abdominal aortic aneurysm (AAA) rupture risk, beyond the traditional measure of maximum aneurysm diameter. A Comprehensive fluid-structure interaction (FSI) analysis was employed to assess risk factors in a range of patient scenarios, with the use of three-dimensional (3D) AAA models reconstructed from patient-specific aortic data and finite element method. Wall shear stress (WSS), and its derivatives such as time-averaged WSS (TAWSS), oscillatory shear index (OSI), relative residence time (RRT) and transverse WSS (transWSS) offer insights into the force dynamics acting on the AAA wall. Emphasis is placed on these WSS-based metrics and seven key geometric indices. By correlating these geometric discrepancies with biomechanical phenomena, this study highlights the novel and profound impact of geometry on risk prediction. This study demonstrates the necessity of a multidimensional assessment approach, future efforts should complement these findings with experimental validations for an applicable approach for clinical use.

除了传统的动脉瘤最大直径测量方法外,本文还对几何特征对腹主动脉瘤(AAA)破裂风险的影响进行了前沿计算研究。该研究采用综合流体-结构相互作用(FSI)分析方法,利用根据患者特异性主动脉数据重建的三维(3D)AAA 模型和有限元方法,评估一系列患者情况下的风险因素。壁剪切应力(WSS)及其衍生物,如时间平均剪切应力(TAWSS)、振荡剪切指数(OSI)、相对停留时间(RRT)和横向剪切应力(transWSS),有助于深入了解作用在 AAA 壁上的力的动态变化。重点是这些基于 WSS 的指标和七个关键的几何指数。通过将这些几何差异与生物力学现象相关联,本研究强调了几何对风险预测的新颖而深刻的影响。这项研究证明了多维评估方法的必要性,未来的工作应通过实验验证来补充这些发现,从而将适用的方法用于临床。
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引用次数: 0
Numerical Simulations for Calibration Setup for Dynamic Contrast-Enhanced Ultrasonography Imaging Protocol. 动态对比增强超声成像协议校准设置的数值模拟。
IF 2.2 4区 医学 Q3 ENGINEERING, BIOMEDICAL Pub Date : 2024-11-09 DOI: 10.1002/cnm.3885
Abderahmane Marouf, Ahmed G Rahma, Isaline Hoferer, Charly Girot, Stephanie Pitre-Champagnat, Yannick Hoarau

This study presents an investigation of an innovative microfluidic flow separator using both numerical and experimental approaches to calibrate contrast-enhanced ultrasound scanners. Numerical simulations were conducted using Lagrangian particles tracking and passive scalar transport methodologies using the OpenFOAM software. The experimental validation confirmed the accuracy of the numerical simulations, particularly at an imposed total pressure of 0.7 P 0 $$ 0.7 {P}_0 $$ , showing an excellent agreement in particle distributions. The study emphasizes the computational efficiency and modeling of passive scalar transport, providing valuable understanding into the behavior of scalar quantities in microfluidic systems. An optimized diffusion coefficient value of 10 - 7 m 2 s - 1 $$ {10}^{-7} {m}^2 {s}^{-1} $$ was identified, showing its critical role in achieving accurate simulation results and optimizing the performance of microfluidic flow separators for contrast-enhanced ultrasound scanner calibration.

本研究采用数值和实验方法对创新型微流体流动分离器进行了研究,以校准对比增强超声扫描仪。使用 OpenFOAM 软件的拉格朗日粒子跟踪和被动标量传输方法进行了数值模拟。实验验证证实了数值模拟的准确性,特别是在施加的总压力为 0.7 P 0 $$ 0.7 {P}_0 $$ 时,显示出粒子分布的极佳一致性。这项研究强调了被动标量传输的计算效率和建模,为了解微流控系统中标量的行为提供了宝贵的资料。研究确定了扩散系数的优化值为 10 - 7 m 2 s - 1 $$ {10}^{-7} {m}^2 {s}^{-1} $$,这表明扩散系数对获得精确的模拟结果和优化微流控分离器的性能至关重要,可用于对比增强超声扫描仪的校准。
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引用次数: 0
Therapeutic Effect of Targeted Deployment Filling Coils in the Treatment of Intracranial Aneurysms. 靶向部署填充线圈在治疗颅内动脉瘤中的疗效。
IF 2.2 4区 医学 Q3 ENGINEERING, BIOMEDICAL Pub Date : 2024-11-06 DOI: 10.1002/cnm.3880
Xiaoyu Ren, Bin Gao, Wangsheng Lu, Guangming Yang, Yunjie Wang, Yin Yin

Endovascular coil embolization is the primary therapeutic modality for intracranial aneurysms. Substantial reports have been found regarding the coil packing density and inflow jet. However, the hemodynamic effect of increasing the rate of tamponade in the inflow jet area within the aneurysm remains unclear. In this study, individualized geometries of six intracranial aneurysms were recruited: all six aneurysms were located in the internal carotid artery. Two groups were created by changing the position and orientation of the microcatheter for the release of the third segment of the filling coil. The finite element method was used to simulate coil deployment. Computational fluid dynamics was used to characterize hemodynamics in post-deployment aneurysms. The parameters evaluated included velocity reduction, wall shear stress (WSS), low WSS (LWSS), relative residence time (RRT), flow kinetic energy in the neck region of the aneurysms, and residual flow volume (RFV) in the aneurysms. At the peak time (t = 0.17 s), the targeted deployment group has similar proportion of LWSS area to conventional deployment groups: targeted 78.13% ± 34.59% versus normal 74.20% ± 36.94% (mean ± SD, p = 0.583). The targeted deployment group has a higher RRT area (targeted 16.84% ± 5.58% vs. normal 6.42% ± 5.67% [mean ± SD, p = 0.009]), smaller flow kinetic energy (targeted 9.43 ± 4.33 vs. normal 16.23 ± 5.92 [mean ± SD, p = 0.047]), and a larger RFV in the aneurysms (targeted 35.97 ± 24.35 mm3 vs. normal 25.80 ± 18.94 mm3 [mean ± SD, p = 0.44]). Inflow jets play an important role in the treatment of aneurysms, and deploying filling coils in accordance with inflow jets may result in a better hemodynamic environment.

血管内线圈栓塞是治疗颅内动脉瘤的主要方法。有关线圈填塞密度和流入喷射的报道很多。然而,增加动脉瘤内流入射流区域的填塞率对血液动力学的影响仍不清楚。在这项研究中,研究人员采集了六个颅内动脉瘤的个性化几何形状:所有六个动脉瘤都位于颈内动脉。通过改变微导管的位置和方向来释放填充线圈的第三段,创建了两组。使用有限元法模拟线圈的展开。计算流体动力学用于描述部署后动脉瘤的血液动力学特征。评估的参数包括速度降低、壁切应力(WSS)、低WSS(LWSS)、相对停留时间(RRT)、动脉瘤颈部的流动动能以及动脉瘤内的残余血流量(RFV)。在峰值时间(t = 0.17 秒),靶向部署组的 LWSS 面积比例与常规部署组相似:靶向 78.13% ± 34.59% 对常规 74.20% ± 36.94%(平均值 ± SD,P = 0.583)。靶向部署组的 RRT 面积更大(靶向 16.84% ± 5.58% vs. 正常 6.42% ± 5.67% [平均值 ± 标准差,p = 0.009]),流动动能更小(靶向 9.43 ± 4.33 vs. 正常值 16.23 ± 5.92 [平均值±标准差,p = 0.047]),动脉瘤中的 RFV 较大(目标值 35.97 ± 24.35 mm3 vs. 正常值 25.80 ± 18.94 mm3 [平均值±标准差,p = 0.44])。血流喷射在动脉瘤的治疗中起着重要作用,根据血流喷射部署填充线圈可能会带来更好的血液动力学环境。
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引用次数: 0
Modeling Fibrin Accumulation on Flow-Diverting Devices for Intracranial Aneurysms. 颅内动脉瘤分流装置上的纤维蛋白聚集模型。
IF 2.2 4区 医学 Q3 ENGINEERING, BIOMEDICAL Pub Date : 2024-11-05 DOI: 10.1002/cnm.3883
Juan R Cebral, Fernando Mut, Rainald Löhner, Laurel Marsh, Alireza Chitsaz, Cem Bilgin, Esref Bayraktar, David Kallmes, Ramanathan Kadirvel

The mechanisms leading to aneurysm occlusion after treatment with flow-diverting devices are not fully understood. Flow modification induces thrombus formation within the aneurysm cavity, but fibrin can simultaneously accumulate and cover the device scaffold, leading to further flow modification. However, the interplay and relative importance of these processes are not clearly understood. A computational model of fibrin accumulation and flow modification after flow diversion treatment of cerebral aneurysms has been developed under the guidance of in vitro experiments and observations. The model is based on the loose coupling of flow and transport-reaction equations that are solved separately by independent codes. Interaction or reactive terms account for thrombin production from prothrombin stimulated by thrombogenic metallic wires and inhibition by antithrombin as well as fibrin production from fibrinogen stimulated by thrombin and flow shear stress, and fibrin adhesion to device wires and already attached fibrin. The computational model was demonstrated and tested on idealized vessel and aneurysm geometries. The model was able to reproduce the salient features of fibrin accumulation after the deployment of flow-diverting devices in idealized in vitro models of cerebral aneurysms. Namely, fibrin production in regions of high shear stress, initial accumulation at the inflow zone, and progressive occlusion of the device and corresponding flow attenuation. The computational model linking flow dynamics to fibrin production, transport, and adhesion can be used to investigate and better understand the effects that lead to fibrin accumulation and the resulting aneurysm inflow reduction and intra-aneurysmal flow modulation.

使用分流装置治疗后导致动脉瘤闭塞的机制尚未完全明了。血流改变会诱导动脉瘤腔内血栓形成,但纤维蛋白会同时积聚并覆盖装置支架,导致血流进一步改变。然而,人们对这些过程的相互作用和相对重要性并不清楚。在体外实验和观察的指导下,我们建立了脑动脉瘤血流分流治疗后纤维蛋白积聚和血流改变的计算模型。该模型基于流动和传输-反应方程的松散耦合,这些方程由独立的代码分别求解。相互作用或反应项解释了凝血酶原在血栓形成金属丝的刺激下产生凝血酶和抗凝血酶的抑制作用,以及纤维蛋白原在凝血酶和流动剪应力的刺激下产生纤维蛋白,以及纤维蛋白粘附到装置金属丝和已经附着的纤维蛋白上。计算模型在理想化的血管和动脉瘤几何形状上进行了演示和测试。该模型能够再现在理想化的体外脑动脉瘤模型中部署导流装置后纤维蛋白积聚的显著特点。即,在高剪切应力区域产生纤维蛋白、在流入区初始积聚、装置逐渐闭塞以及相应的血流衰减。将流动动力学与纤维蛋白的产生、运输和粘附联系起来的计算模型可用于研究和更好地理解导致纤维蛋白积聚的效应,以及由此引起的动脉瘤流入量减少和动脉瘤内血流调节。
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引用次数: 0
PREPRINT Machine Learning for the Sensitivity Analysis of a Model of the Cellular Uptake of Nanoparticles for the Treatment of Cancer. PREPRINT 用于治疗癌症的纳米粒子细胞吸收模型敏感性分析的机器学习。
IF 2.2 4区 医学 Q3 ENGINEERING, BIOMEDICAL Pub Date : 2024-10-29 DOI: 10.1002/cnm.3878
Sarah Iaquinta, Shahram Khazaie, Samer Albanna, Sylvain Fréour, Frédéric Jacquemin

Experimental studies on the cellular uptake of nanoparticles (NPs), useful for the investigation of NP-based drug delivery systems, are often difficult to interpret due to the large number of parameters that can contribute to the phenomenon. It is therefore of great interest to identify insignificant parameters to reduce the number of variables used for the design of experiments. In this work, a model of the wrapping of elliptical NPs by the cell membrane is used to compare the influence of the aspect ratio of the NP, the membrane tension, the NP-membrane adhesion, and its variation during the interaction with the NP on the equilibrium state of the wrapping process. Several surrogate models, such as Kriging, Polynomial Chaos Expansion (PCE), and artificial neural networks (ANN) have been built and compared to emulate the computationally expensive model. Only the ANN-based model outperformed the other approaches by providing much better predictivity metrics and could therefore be used to compute the sensitivity indices. Our results showed that the NP's aspect ratio, the initial NP-membrane adhesion, the membrane tension, and the delay for the increase of the NP-membrane adhesion after receptor dynamics are the main contributors to the cellular internalization of the NP, while the influence of other parameters is negligible.

纳米粒子(NPs)的细胞摄取实验研究对基于 NP 的给药系统的研究非常有用,但由于造成这种现象的参数众多,往往难以解释。因此,找出不重要的参数以减少用于实验设计的变量数量是非常有意义的。在这项工作中,使用了细胞膜包裹椭圆形 NP 的模型,以比较 NP 的长宽比、膜张力、NP-膜粘附力及其在与 NP 相互作用过程中的变化对包裹过程平衡状态的影响。我们建立并比较了克里金法、多项式混沌展开法(PCE)和人工神经网络(ANN)等几种代用模型,以模拟计算成本高昂的模型。只有基于人工神经网络的模型优于其他方法,能提供更好的预测性指标,因此可用于计算灵敏度指数。我们的结果表明,NP 的长宽比、NP 与膜的初始粘附力、膜张力以及受体动力学后 NP 与膜粘附力增加的延迟是 NP 细胞内化的主要因素,而其他参数的影响可以忽略不计。
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引用次数: 0
期刊
International Journal for Numerical Methods in Biomedical Engineering
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