Emulsion-templated macroporous polycaprolactone: Synthesis, degradation, additive manufacturing, and cell-growth

IF 4.1 2区 化学 Q2 POLYMER SCIENCE Polymer Pub Date : 2024-12-20 DOI:10.1016/j.polymer.2024.127971
Bar Shlomo-Avitan, Majd Machour, Samah Saied Ahmad, Yoav Friedler, Shulamit Levenberg, Michael S. Silverstein
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Abstract

PolyHIPEs are macroporous polymers templated within high internal phase emulsions (HIPEs). The ability to tailor the macromolecular and porous structures makes polyHIPEs of interest for three dimensional tissue engineering scaffolds. In this work, polyHIPEs with densities ranging from 0.18 to 0.28 g/cc were synthesized from novel biodegradable poly(ɛ-caprolactone) (PCL) macromers based on methacrylated oligomeric PCL diols of various molecular weights. Different types of internal phases generated porous structures that varied from networks of channels to highly interconnected voids. The crosslinked macromolecular structure limited PCL crystallization, resulting in elastomeric behavior with moduli of around 20 kPa. The HIPEs proved suitable for 3D printing both in air and in an innovative gel-bath. The suitability of the polyHIPEs for tissue engineering applications was indicated by their moduli, by their complete degradation within 4 h in 3 M NaOH, and by the mesenchymal stem cells adhering and proliferating. The high level of viability can be attributed to the porosity that enables sufficient nutrient and waste diffusion. These results provide a foundation for designing 3D HIPE inks for printing macroporous tissue engineering scaffolds.

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来源期刊
Polymer
Polymer 化学-高分子科学
CiteScore
7.90
自引率
8.70%
发文量
959
审稿时长
32 days
期刊介绍: Polymer is an interdisciplinary journal dedicated to publishing innovative and significant advances in Polymer Physics, Chemistry and Technology. We welcome submissions on polymer hybrids, nanocomposites, characterisation and self-assembly. Polymer also publishes work on the technological application of polymers in energy and optoelectronics. The main scope is covered but not limited to the following core areas: Polymer Materials Nanocomposites and hybrid nanomaterials Polymer blends, films, fibres, networks and porous materials Physical Characterization Characterisation, modelling and simulation* of molecular and materials properties in bulk, solution, and thin films Polymer Engineering Advanced multiscale processing methods Polymer Synthesis, Modification and Self-assembly Including designer polymer architectures, mechanisms and kinetics, and supramolecular polymerization Technological Applications Polymers for energy generation and storage Polymer membranes for separation technology Polymers for opto- and microelectronics.
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