{"title":"Glyphosate-based herbicide metabolic profiles in human urine samples through proton nuclear magnetic resonance analysis.","authors":"Preechaya Tajai, Giatgong Konguthaithip, Thanyaphisit Chaikhaeng, Churdsak Jaikang","doi":"10.5599/admet.2476","DOIUrl":null,"url":null,"abstract":"<p><strong>Background and purpose: </strong>Glyphosate-based herbicides, extensively utilized worldwide, raise concerns regarding potential human risks due to the detection of glyphosate (GLY) in human body fluids. This study aims to address critical knowledge gaps regarding whether GLY undergoes metabolism in humans, particularly considering the limited information available on human metabolism.</p><p><strong>Experimental approach: </strong>The study investigated GLY and its metabolites in eight amenity horticultural workers using proton nuclear magnetic resonance (<sup>1</sup>H-NMR) data analysis. Multiple spot urine samples were collected before and after herbicide applications.</p><p><strong>Key results: </strong>Findings reveal the presence of GLY and its metabolites (AMPA, formaldehyde, sarcosine, glyoxylic acid, and methylamine). Results demonstrate a moderate correlation between median GLY concentration and its metabolites within the studied population.</p><p><strong>Conclusion: </strong>Persuasive evidence suggests the potential metabolism of GLY in humans. <sup>1</sup>H-NMR data analysis might be a promising technique for determining the metabolism of GLY in humans, offering valuable insights into urinary excretion patterns.</p>","PeriodicalId":7259,"journal":{"name":"ADMET and DMPK","volume":"12 6","pages":"957-970"},"PeriodicalIF":3.4000,"publicationDate":"2024-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11661807/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"ADMET and DMPK","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5599/admet.2476","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}
引用次数: 0
Abstract
Background and purpose: Glyphosate-based herbicides, extensively utilized worldwide, raise concerns regarding potential human risks due to the detection of glyphosate (GLY) in human body fluids. This study aims to address critical knowledge gaps regarding whether GLY undergoes metabolism in humans, particularly considering the limited information available on human metabolism.
Experimental approach: The study investigated GLY and its metabolites in eight amenity horticultural workers using proton nuclear magnetic resonance (1H-NMR) data analysis. Multiple spot urine samples were collected before and after herbicide applications.
Key results: Findings reveal the presence of GLY and its metabolites (AMPA, formaldehyde, sarcosine, glyoxylic acid, and methylamine). Results demonstrate a moderate correlation between median GLY concentration and its metabolites within the studied population.
Conclusion: Persuasive evidence suggests the potential metabolism of GLY in humans. 1H-NMR data analysis might be a promising technique for determining the metabolism of GLY in humans, offering valuable insights into urinary excretion patterns.
期刊介绍：
ADMET and DMPK is an open access journal devoted to the rapid dissemination of new and original scientific results in all areas of absorption, distribution, metabolism, excretion, toxicology and pharmacokinetics of drugs. ADMET and DMPK publishes the following types of contributions: - Original research papers - Feature articles - Review articles - Short communications and Notes - Letters to Editors - Book reviews The scope of the Journal involves, but is not limited to, the following areas: - physico-chemical properties of drugs and methods of their determination - drug permeabilities - drug absorption - drug-drug, drug-protein, drug-membrane and drug-DNA interactions - chemical stability and degradations of drugs - instrumental methods in ADMET - drug metablic processes - routes of administration and excretion of drug - pharmacokinetic/pharmacodynamic study - quantitative structure activity/property relationship - ADME/PK modelling - Toxicology screening - Transporter identification and study
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