Zhi Li, Yu Han, Xiaoqing Huang, Wenjuan Xiong, Yuanyuan Su, Tingkai Cui, Xin Zhang, Shanshan Cui
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引用次数: 0
Abstract
This study aimed to determine the relationship between individual and combined phthalate metabolites and body composition in children and adolescents using data from the 2015-2018 National Health and Nutrition Examination Survey. Single-exposure analysis indicated that most phthalate metabolites were negatively correlated with areal bone mineral density (aBMD). Quantile g-computation demonstrated a negative relationship between the mixture of phthalate metabolites and aBMD, which was confirmed by the Bayesian kernel machine regression model. Sex-stratified analysis revealed that mono-butyl phthalate (MBP) was negatively correlated with aBMD, and MBP, mono-ethyl phthalate (MEP), and mono-isobutyl phthalate (MiBP) were negatively linked to lean mass in males but not in females. The results did not differ according to developmental stages (childhood vs. adolescence). Our findings indicate that phthalate metabolites may affect the body composition in children and adolescents, particularly aBMD. Certain phthalate metabolites seem to be sex-specific, with males showing higher sensitivity than females.
期刊介绍:
International Journal of Environmental Health Research ( IJEHR ) is devoted to the rapid publication of research in environmental health, acting as a link between the diverse research communities and practitioners in environmental health. Published articles encompass original research papers, technical notes and review articles. IJEHR publishes articles on all aspects of the interaction between the environment and human health. This interaction can broadly be divided into three areas: the natural environment and health – health implications and monitoring of air, water and soil pollutants and pollution and health improvements and air, water and soil quality standards; the built environment and health – occupational health and safety, exposure limits, monitoring and control of pollutants in the workplace, and standards of health; and communicable diseases – disease spread, control and prevention, food hygiene and control, and health aspects of rodents and insects. IJEHR is published in association with the International Federation of Environmental Health and includes news from the Federation of international meetings, courses and environmental health issues.