Associations between phthalate metabolites and body composition in children aged 8-19 years.

IF 2.2 4区 医学 Q3 ENVIRONMENTAL SCIENCES International Journal of Environmental Health Research Pub Date : 2024-12-23 DOI:10.1080/09603123.2024.2445159
Zhi Li, Yu Han, Xiaoqing Huang, Wenjuan Xiong, Yuanyuan Su, Tingkai Cui, Xin Zhang, Shanshan Cui
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Abstract

This study aimed to determine the relationship between individual and combined phthalate metabolites and body composition in children and adolescents using data from the 2015-2018 National Health and Nutrition Examination Survey. Single-exposure analysis indicated that most phthalate metabolites were negatively correlated with areal bone mineral density (aBMD). Quantile g-computation demonstrated a negative relationship between the mixture of phthalate metabolites and aBMD, which was confirmed by the Bayesian kernel machine regression model. Sex-stratified analysis revealed that mono-butyl phthalate (MBP) was negatively correlated with aBMD, and MBP, mono-ethyl phthalate (MEP), and mono-isobutyl phthalate (MiBP) were negatively linked to lean mass in males but not in females. The results did not differ according to developmental stages (childhood vs. adolescence). Our findings indicate that phthalate metabolites may affect the body composition in children and adolescents, particularly aBMD. Certain phthalate metabolites seem to be sex-specific, with males showing higher sensitivity than females.

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邻苯二甲酸酯代谢物与8-19岁儿童身体成分的关系
本研究旨在利用2015-2018年全国健康与营养检查调查的数据,确定儿童和青少年个体和联合邻苯二甲酸酯代谢物与身体成分之间的关系。单次暴露分析表明,大多数邻苯二甲酸酯代谢物与面积骨矿物质密度(aBMD)呈负相关。分位数g计算表明邻苯二甲酸酯代谢物混合物与aBMD呈负相关,贝叶斯核机回归模型证实了这一点。性别分层分析显示,邻苯二甲酸一丁酯(MBP)与aBMD呈负相关,MBP、邻苯二甲酸一乙酯(MEP)和邻苯二甲酸一异丁酯(MiBP)与男性瘦体重呈负相关,而在女性中没有。根据发育阶段(儿童期和青春期),结果没有差异。我们的研究结果表明,邻苯二甲酸酯代谢物可能影响儿童和青少年的身体组成,特别是aBMD。某些邻苯二甲酸酯代谢物似乎是性别特异性的,男性比女性表现出更高的敏感性。
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来源期刊
International Journal of Environmental Health Research
International Journal of Environmental Health Research 医学-公共卫生、环境卫生与职业卫生
CiteScore
6.70
自引率
3.10%
发文量
134
审稿时长
>12 weeks
期刊介绍: International Journal of Environmental Health Research ( IJEHR ) is devoted to the rapid publication of research in environmental health, acting as a link between the diverse research communities and practitioners in environmental health. Published articles encompass original research papers, technical notes and review articles. IJEHR publishes articles on all aspects of the interaction between the environment and human health. This interaction can broadly be divided into three areas: the natural environment and health – health implications and monitoring of air, water and soil pollutants and pollution and health improvements and air, water and soil quality standards; the built environment and health – occupational health and safety, exposure limits, monitoring and control of pollutants in the workplace, and standards of health; and communicable diseases – disease spread, control and prevention, food hygiene and control, and health aspects of rodents and insects. IJEHR is published in association with the International Federation of Environmental Health and includes news from the Federation of international meetings, courses and environmental health issues.
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