From gut to kidney: microbiota modulates stone risk through inflammation-a mediated Mendelian randomization study.

IF 2.7 4区 生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Mammalian Genome Pub Date : 2025-03-01 Epub Date: 2024-12-24 DOI:10.1007/s00335-024-10094-9
Long Guo, Qing Lan, Min Zhou, Fei Liu
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Abstract

The gut microbiota (GM) can affect the immune system, which can lead to a variety of diseases, as confirmed by many studies. However, the exact mechanism by which GM affects kidney stone incidence through the immune system remains unclear. This study used a two-step, two-sample Mendelian randomization (MR) analysis by inverse variance weighting (IVW) method as well as Bayesian weighting (BWMR) to find out how the gut microbiota and inflammatory cytokines contribute to kidney stones, followed by a mediated MR analysis to exploreHow inflammatory cytokines are involved in the connection with the gut microbiota and kidney stones. MR analysis revealed that seven intestinal flora were protective against kidney stones, including family. Actinomycetaceae, family.Clostridiaceae1, genus.Clostridiumsensustricto1, genus. Hungatella, genus.LachnospiraceaeUCG001, genus.LachnospiraceaeUCG008 and order. Actinomycetales, while four intestinal flora, including genus. Haemophilus, genus. RuminococcaceaeUCG010, order.Rhodospirillales and phylum.Actinobacteria may increase the risk of kidney stones. In addition, it was confirmed that seven Inflammatory cytokines DNER, IL-18, IL-1α, SLAMF1, STAMPB, CST5 and FGF-5 in association with kidney stones. Notably, the mediating MR indicated the causal effect of phylum. Actinobacteria and order. Rhodospirillales gut group on kidney stones was mainly modulated by IL-18 levels, with mediating effects accounting for 15.8% and 12.8% of the total effect, respectively. The present study demonstrates this phylum. Actinobacteria and order. Rhodospirillales flora have an important role in reducing the risk of kidney stones and act mainly by modulating IL-18 levels.

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从肠道到肾脏:微生物群通过炎症调节结石风险——一项介导的孟德尔随机研究。
正如许多研究证实的那样,肠道微生物群(GM)可以影响免疫系统,从而导致多种疾病。然而,转基因通过免疫系统影响肾结石发病率的确切机制尚不清楚。本研究采用反方差加权(IVW)法和贝叶斯加权(BWMR)的两步、两样本孟德尔随机化(MR)分析来了解肠道微生物群和炎症细胞因子是如何导致肾结石的,然后通过介导的MR分析来探索炎症细胞因子如何参与肠道微生物群和肾结石的关联。核磁共振分析显示,7种肠道菌群对肾结石有保护作用,包括家族。放线菌科、家庭。Clostridiaceae1,属。Clostridiumsensustricto1,属。Hungatella,属。LachnospiraceaeUCG001,属。lachnospiraceucg008并订购。放线菌属,而肠道菌群包括四属。嗜血杆菌属。RuminococcaceaeUCG010,秩序。红螺旋菌门。放线菌可能会增加患肾结石的风险。此外,证实了7种炎症细胞因子DNER、IL-18、IL-1α、SLAMF1、STAMPB、CST5和FGF-5与肾结石相关。值得注意的是,介导的MR表明门的因果作用。放线菌与秩序。红螺旋菌肠道组对肾结石的作用主要受IL-18水平的调节,其介导作用分别占总效应的15.8%和12.8%。目前的研究证实了这一门。放线菌与秩序。红螺旋菌群在降低肾结石风险中起重要作用,主要通过调节IL-18水平起作用。
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来源期刊
Mammalian Genome
Mammalian Genome 生物-生化与分子生物学
CiteScore
4.00
自引率
0.00%
发文量
33
审稿时长
6-12 weeks
期刊介绍: Mammalian Genome focuses on the experimental, theoretical and technical aspects of genetics, genomics, epigenetics and systems biology in mouse, human and other mammalian species, with an emphasis on the relationship between genotype and phenotype, elucidation of biological and disease pathways as well as experimental aspects of interventions, therapeutics, and precision medicine. The journal aims to publish high quality original papers that present novel findings in all areas of mammalian genetic research as well as review articles on areas of topical interest. The journal will also feature commentaries and editorials to inform readers of breakthrough discoveries as well as issues of research standards, policies and ethics.
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