{"title":"Associations between vaping during pregnancy and perinatal outcomes: A systematic review and meta-analysis","authors":"Andy Deprato , Arundhati Garud , Danila Azzolina , Nicola Murgia , Margie H. Davenport , Padma Kaul , Paige Lacy , Subhabrata Moitra","doi":"10.1016/j.jhazmat.2024.137028","DOIUrl":null,"url":null,"abstract":"<div><div>Despite numerous studies linking prenatal vaping to adverse perinatal outcomes, a systematic assessment for critical comparison remains absent. To investigate these associations, we conducted a systematic search of studies assessing perinatal outcomes in mothers and/or neonates exposed to vaping during pregnancy compared to those in women without prenatal vaping exposure through MEDLINE, EMBASE, Scopus, Web of Science, Cochrane Library, PROSPERO, and Google Scholar until July 5, 2024. We performed inverse-variance random-effects meta-analyses for maternal and neonatal outcomes of 23 studies with a total of 924,376 participants with 7552 reporting vaping-only use during pregnancy. Prenatal vaping was associated with 53 % higher odds of an adverse maternal outcome (OR: 1.53; 95 % CI: 1.27–1.85; I<sup>2</sup> = 80 %), particularly with decreased breastfeeding (OR: 0.53; 95 % CI: 0.38–0.72; I<sup>2</sup> = 45 %) and reduced prevalence of adequate prenatal care (OR: 0.69; 95 % CI: 0.56–0.86; I<sup>2</sup> = 82 %). Prenatal vaping was also associated with a similarly 53 % higher odds of an adverse neonatal outcome (OR: 1.53; 95 % CI: 1.34–1.76; I<sup>2</sup> = 45 %), such as low birth weight (OR: 1.56; 95 % CI: 1.28–1.93; I<sup>2</sup>: 15 %), preterm birth (OR: 1.49; 955 CI: 1.27–1.76; I<sup>2</sup>: 0 %), and small for gestational age (OR: 1.48; 955 CI: 1.16–1.89; I<sup>2</sup>: 70 %). This is the first comprehensive systematic review and meta-analysis demonstrating vaping during pregnancy as a risk factor for increased odds of both maternal and neonatal outcomes and underscores the urgency to address awareness and regulations of vaping and its potential harms to both humans and the environment.</div></div><div><h3>Registration</h3><div>PROSPERO CRD42023446266.</div></div>","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"486 ","pages":"Article 137028"},"PeriodicalIF":12.2000,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Hazardous Materials","FirstCategoryId":"93","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0304389424036094","RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENGINEERING, ENVIRONMENTAL","Score":null,"Total":0}
引用次数: 0
Abstract
Despite numerous studies linking prenatal vaping to adverse perinatal outcomes, a systematic assessment for critical comparison remains absent. To investigate these associations, we conducted a systematic search of studies assessing perinatal outcomes in mothers and/or neonates exposed to vaping during pregnancy compared to those in women without prenatal vaping exposure through MEDLINE, EMBASE, Scopus, Web of Science, Cochrane Library, PROSPERO, and Google Scholar until July 5, 2024. We performed inverse-variance random-effects meta-analyses for maternal and neonatal outcomes of 23 studies with a total of 924,376 participants with 7552 reporting vaping-only use during pregnancy. Prenatal vaping was associated with 53 % higher odds of an adverse maternal outcome (OR: 1.53; 95 % CI: 1.27–1.85; I2 = 80 %), particularly with decreased breastfeeding (OR: 0.53; 95 % CI: 0.38–0.72; I2 = 45 %) and reduced prevalence of adequate prenatal care (OR: 0.69; 95 % CI: 0.56–0.86; I2 = 82 %). Prenatal vaping was also associated with a similarly 53 % higher odds of an adverse neonatal outcome (OR: 1.53; 95 % CI: 1.34–1.76; I2 = 45 %), such as low birth weight (OR: 1.56; 95 % CI: 1.28–1.93; I2: 15 %), preterm birth (OR: 1.49; 955 CI: 1.27–1.76; I2: 0 %), and small for gestational age (OR: 1.48; 955 CI: 1.16–1.89; I2: 70 %). This is the first comprehensive systematic review and meta-analysis demonstrating vaping during pregnancy as a risk factor for increased odds of both maternal and neonatal outcomes and underscores the urgency to address awareness and regulations of vaping and its potential harms to both humans and the environment.
期刊介绍:
The Journal of Hazardous Materials serves as a global platform for promoting cutting-edge research in the field of Environmental Science and Engineering. Our publication features a wide range of articles, including full-length research papers, review articles, and perspectives, with the aim of enhancing our understanding of the dangers and risks associated with various materials concerning public health and the environment. It is important to note that the term "environmental contaminants" refers specifically to substances that pose hazardous effects through contamination, while excluding those that do not have such impacts on the environment or human health. Moreover, we emphasize the distinction between wastes and hazardous materials in order to provide further clarity on the scope of the journal. We have a keen interest in exploring specific compounds and microbial agents that have adverse effects on the environment.